NEOLI_001268 protein (Neolecta irregularis) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

NEOLI_001268

Histone transcription regulator 3. (1662 aa)

Predicted Functional Partners:

NEOLI_001493

0.827

NEOLI_002025

0.812

NEOLI_002554

0.806

NEOLI_004363

0.803

NEOLI_004393

0.799

NEOLI_000791

0.789

NEOLI_004176

0.780

NEOLI_002935

0.779

NEOLI_001016

0.724

NEOLI_000325

0.720

Your Current Organism:

Neolecta irregularis

NCBI taxonomy Id: 1198029
Other names: N. irregularis DAH-3, Neolecta irregularis DAH-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NEOLI_000325	NEOLI_001268	A0A1U7LVM5	A0A1U7LV31	DNA replication ATP-dependent helicase/nuclease dna2.	Histone transcription regulator 3.	0.720
NEOLI_000325	NEOLI_001493	A0A1U7LVM5	A0A1U7LQJ1	DNA replication ATP-dependent helicase/nuclease dna2.	DNA polymerase subunit delta-2.	0.779
NEOLI_000325	NEOLI_004176	A0A1U7LVM5	A0A1U7LLB4	DNA replication ATP-dependent helicase/nuclease dna2.	Crossover junction endonuclease mus81.	0.867
NEOLI_000325	NEOLI_004393	A0A1U7LVM5	A0A1U7LPL7	DNA replication ATP-dependent helicase/nuclease dna2.	DNA polymerase; Belongs to the universal ribosomal protein uS8 family.	0.887
NEOLI_000791	NEOLI_001016	A0A1U7LWT3	A0A1U7LW86	Small nuclear ribonucleoprotein F.	Small nuclear ribonucleoprotein-associated protein B.	0.996
NEOLI_000791	NEOLI_001268	A0A1U7LWT3	A0A1U7LV31	Small nuclear ribonucleoprotein F.	Histone transcription regulator 3.	0.789
NEOLI_000791	NEOLI_002025	A0A1U7LWT3	A0A1U7LTB9	Small nuclear ribonucleoprotein F.	Survival motor neuron-like protein 1.	0.952
NEOLI_000791	NEOLI_002554	A0A1U7LWT3	A0A1U7LJ47	Small nuclear ribonucleoprotein F.	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.	0.999
NEOLI_000791	NEOLI_002935	A0A1U7LWT3	A0A1U7LS01	Small nuclear ribonucleoprotein F.	Small nuclear ribonucleoprotein G.	0.999
NEOLI_000791	NEOLI_004363	A0A1U7LWT3	A0A1U7LLA9	Small nuclear ribonucleoprotein F.	Small nuclear ribonucleoprotein Sm D2.	0.999
NEOLI_001016	NEOLI_000791	A0A1U7LW86	A0A1U7LWT3	Small nuclear ribonucleoprotein-associated protein B.	Small nuclear ribonucleoprotein F.	0.996
NEOLI_001016	NEOLI_001268	A0A1U7LW86	A0A1U7LV31	Small nuclear ribonucleoprotein-associated protein B.	Histone transcription regulator 3.	0.724
NEOLI_001016	NEOLI_002025	A0A1U7LW86	A0A1U7LTB9	Small nuclear ribonucleoprotein-associated protein B.	Survival motor neuron-like protein 1.	0.860
NEOLI_001016	NEOLI_002554	A0A1U7LW86	A0A1U7LJ47	Small nuclear ribonucleoprotein-associated protein B.	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.	0.998
NEOLI_001016	NEOLI_002935	A0A1U7LW86	A0A1U7LS01	Small nuclear ribonucleoprotein-associated protein B.	Small nuclear ribonucleoprotein G.	0.995
NEOLI_001016	NEOLI_004363	A0A1U7LW86	A0A1U7LLA9	Small nuclear ribonucleoprotein-associated protein B.	Small nuclear ribonucleoprotein Sm D2.	0.997
NEOLI_001268	NEOLI_000325	A0A1U7LV31	A0A1U7LVM5	Histone transcription regulator 3.	DNA replication ATP-dependent helicase/nuclease dna2.	0.720
NEOLI_001268	NEOLI_000791	A0A1U7LV31	A0A1U7LWT3	Histone transcription regulator 3.	Small nuclear ribonucleoprotein F.	0.789
NEOLI_001268	NEOLI_001016	A0A1U7LV31	A0A1U7LW86	Histone transcription regulator 3.	Small nuclear ribonucleoprotein-associated protein B.	0.724
NEOLI_001268	NEOLI_001493	A0A1U7LV31	A0A1U7LQJ1	Histone transcription regulator 3.	DNA polymerase subunit delta-2.	0.827

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Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.701

expected number of edges:

10

PPI enrichment p-value:

7.98e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

11 of 24

2.26

8.41

1.92e-21

GO:0050896

Response to stimulus

11 of 334

1.11

1.61

2.89e-11

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016987

Sigma factor activity

11 of 24

2.26

8.48

1.09e-21

GO:0003677

DNA binding

11 of 369

1.07

1.45

3.36e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1196

0.56

0.49

8.24e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6080

RNA polymerase sigma-70 like, and Sigma factor antagonist activity

10 of 35

2.05

6.17

5.00e-17

CL:6082

RNA polymerase sigma-70 like, and Sigma factor antagonist activity

8 of 28

2.05

5.1

3.69e-13

CL:6084

RNA polymerase sigma-70 like, and FecR protein

7 of 22

2.1

4.7

1.65e-11

CL:6109

Sigma-70, region 4

4 of 6

2.42

3.18

7.33e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 478

0.96

1.16

4.17e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

11 of 55

1.9

5.74

1.17e-18

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0731

Sigma factor

11 of 22

2.3

8.94

1.53e-22

KW-0238

DNA-binding

11 of 178

1.39

2.67

4.04e-14

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04542

Sigma-70 region 2

10 of 19

2.32

8.05

2.09e-19

PF08281

Sigma-70, region 4

8 of 13

2.39

6.76

3.32e-15

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007627

RNA polymerase sigma-70 region 2

11 of 20

2.34

9.0

4.97e-22

IPR039425

RNA polymerase sigma-70 like

11 of 21

2.32

8.89

4.97e-22

IPR014284

RNA polymerase sigma-70 like domain

11 of 22

2.3

8.78

4.97e-22

IPR013325

RNA polymerase sigma factor, region 2

11 of 22

2.3

8.78

4.97e-22

IPR013324

RNA polymerase sigma factor, region 3/4-like

11 of 22

2.3

8.78

4.97e-22

(more ...)

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