STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgA3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (421 aa)    
Predicted Functional Partners:
ACAM_1177
hydroxymethylglutaryl-CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.999
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 0.982
ACAM_1175
Predicted nucleic-acid-binding protein containing a Zn-ribbon.
       0.944
ACAM_1176
3-ketoacyl-CoA thiolase.
  
  
 0.856
fgs
Farnesylgeranyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.715
ACAM_0033
Anthranilate/para-aminobenzoate synthase component I.
     
 0.573
gap
Glyceraldehyde-3-phosphate dehydrogenase.
     
 0.572
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
   
 0.544
ACAM_1178
Predicted Fe-S oxidoreductase.
 
     0.535
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
     
 0.502
Your Current Organism:
Aeropyrum camini
NCBI taxonomy Id: 1198449
Other names: A. camini SY1 = JCM 12091, Aeropyrum camini JCM 12091, Aeropyrum camini JCM 12091 = SY1, Aeropyrum camini SY1, Aeropyrum camini SY1 = JCM 12091
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