STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas1-2CRISPR-associated endonuclease cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (300 aa)    
Predicted Functional Partners:
EPH04073.1
CRISPR-associated endoribonuclease cas2, subtype I-e.
 
 
 0.996
EPH04075.1
CRISPR-associated protein cas6/cse3/case, subtype I-e.
 
  
 0.950
EPH04077.1
CRISPR-associated protein cas7/cse4/casc, subtype I-e.
 
  
 0.947
EPH04076.1
CRISPR-associated protein cas5/casd, subtype I-e.
 
   
 0.937
EPH04079.1
CRISPR type I-e/-associated protein casa/cse1.
 
  
 0.936
EPH04078.1
CRISPR type I-e/-associated protein casb/cse2.
 
  
 0.923
EPH04080.1
CRISPR-associated helicase cas3.
 
  
 0.922
cas2
CRISPR-associated endoribonuclease cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
  
 
 0.909
cas1
CRISPR-associated endonuclease cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
   
 
 0.742
purC
Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family.
    
   0.451
Your Current Organism:
Propionibacterium sp. F0372
NCBI taxonomy Id: 1203605
Other names: P. sp. oral taxon 192 str. F0372, Propionibacterium sp. oral taxon 192 str. F0372
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.