STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hscBMolecular chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (172 aa)    
Predicted Functional Partners:
ST1E_0542
Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 
 0.993
ST1E_0549
Ferredoxin, 2Fe-2S; Energy production and conversion; SecretomeP prediction: 0.2; Protein involved in 2 iron, 2 sulfur cluster binding.
 
  
 0.969
ST1E_0544
Iron-sulfur cluster assembly protein; Posttranslational modification, protein turnover, chaperones; SecretomeP prediction: 0.05; Protein involved in iron-sulfur cluster binding; Belongs to the HesB/IscA family.
 
 
 0.967
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
 
 0.914
ST1E_0546
Molecular chaperone HscA; Posttranslational modification, protein turnover, chaperones; SecretomeP prediction: 0.05; Protein involved in unfolded protein binding; Belongs to the heat shock protein 70 family.
 
 
 0.909
ST1E_0540
Rrf2 family transcriptional regulator, iron-sulfur cluster assembly; Transcription; SecretomeP prediction: 0.08; Protein involved in 2 iron, 2 sulfur cluster binding and regulation of transcription, DNA-dependent.
  
  
 0.860
cyaY
CyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
  
 
 0.812
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.710
ST1E_0319
Monothiol glutaredoxin; Posttranslational modification, protein turnover, chaperones; SecretomeP prediction: 0.04; Protein involved in cell redox homeostasis; Belongs to the glutaredoxin family. Monothiol subfamily.
     
 0.581
erpA
Fe-S cluster assembly scaffold protein; Required for insertion of 4Fe-4S clusters.
  
 
 0.520
Your Current Organism:
Kinetoplastibacterium galatii
NCBI taxonomy Id: 1208921
Other names: C. Kinetoplastibacterium galatii TCC219, Candidatus Kinetoplastibacterium galatii TCC219
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