STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDF83818.1F420-0:Gamma-glutamyl ligase. (397 aa)    
Predicted Functional Partners:
SDG13226.1
Conserved hypothetical protein, cofD-related; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family.
  
 
 0.739
SDF89294.1
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
    
 0.597
SDF81929.1
Dihydrofolate reductase/thymidylate synthase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
    
  0.593
SDG01882.1
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
    
  0.556
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.547
SDG39720.1
Protein of unknown function.
  
     0.520
folE
GTP cyclohydrolase I.
    
  0.484
SDF89218.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase/GTP cyclohydrolase I.
    
  0.484
SDG23878.1
Hypothetical protein.
 
  
  0.472
SDF89148.1
Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
     
 0.470
Your Current Organism:
Facklamia miroungae
NCBI taxonomy Id: 120956
Other names: CCUG 42728, CIP 106764, F. miroungae, Facklamia miroungae Hoyles et al. 2001, Facklamia sp. CCUG 42728, Facklamia sp. CCUG42728, strain A/G13/99/2
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