STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hprKHPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (gluc [...] (311 aa)    
Predicted Functional Partners:
crh
KEGG: toc:Toce_0866 phosphotransferase system, phosphocarrier protein HPr; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein; PFAM: Phosphotransferase system, phosphocarrier HPr protein.
 
 
 
 0.932
ptsI
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
   
 0.760
AEE90879.1
HAMAP: hydrolase ycdX; PFAM: PHP, C-terminal; KEGG: toc:Toce_0847 PHP domain protein; SMART: Polymerase/histidinol phosphatase, N-terminal.
       0.747
AEE90878.1
TIGRFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase; KEGG: toc:Toce_0846 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal; Sugar isomerase (SIS).
     
 0.728
ydbK
SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_2243 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding.
   
   0.682
AEE90876.1
Metal dependent phosphohydrolase; TIGRFAM: Uncharacterised protein family HDIG; PFAM: Metal-dependent phosphohydrolase, HD subdomain; Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: nth:Nther_0147 metal dependent phosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD domain.
       0.669
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
  
 0.637
fruA
TIGRFAM: Phosphotransferase system, fructose IIC component; Phosphotransferase system, fructose-specific IIB subunit; KEGG: cac:CA_C0234 PTS system, fructoso-specific IIBC component; PFAM: Phosphotransferase system, EIIC.
     
 0.620
dat
D-amino acid aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.
     
 0.619
sps
PFAM: Serine/threonine-protein kinase-like domain; PASTA; KEGG: toc:Toce_1032 serine/threonine protein kinase with PASTA sensor(s); SMART: Serine/threonine-protein kinase domain; Tyrosine-protein kinase, catalytic domain; PASTA.
   
 
 0.616
Your Current Organism:
Tepidanaerobacter acetatoxydans
NCBI taxonomy Id: 1209989
Other names: T. acetatoxydans Re1, Tepidanaerobacter acetatoxydans Re1, Tepidanaerobacter acetatoxydans str. Re1, Tepidanaerobacter acetatoxydans strain Re1, Tepidanaerobacter sp. Re1
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