GCA_000820765_00495 protein (Soleaferrea massiliensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

GCA_000820765_00495

Unannotated protein. (60 aa)

Predicted Functional Partners:

GCA_000820765_00494

0.538

Your Current Organism:

Soleaferrea massiliensis

NCBI taxonomy Id: 1211843
Other names: C. Soleaferrea massiliensis AP7, Candidatus Soleaferrea massiliensis AP7, Ruminococcaceae bacterium AP7

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.929

expected number of edges:

11

PPI enrichment p-value:

0.0126

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033744

L-methionine:thioredoxin-disulfide S-oxidoreductase activity

2 of 2

2.43

0.76

0.0416

GO:0008113

Peptide-methionine (S)-S-oxide reductase activity

2 of 2

2.43

0.76

0.0416

GO:0051920

Peroxiredoxin activity

2 of 7

1.89

0.69

0.0494

GO:0016667

Oxidoreductase activity, acting on a sulfur group of donors

3 of 23

1.55

0.68

0.0416

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2884

Mixed, incl. Peptidase M24, and HNH nuclease

5 of 5

2.43

3.79

3.97e-08

CL:3714

Peptide-methionine (R)-S-oxide reductase activity, and Peptide methionine sulfoxide reductase

2 of 5

2.03

0.73

0.0436

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

4 of 44

1.39

1.34

0.00030

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 70

1.19

1.04

0.00085

MAP-5663205

Infectious disease

4 of 77

1.15

1.0

0.00085

MAP-1643685

Disease

4 of 81

1.13

0.98

0.00085

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10417

C-terminal domain of 1-Cys peroxiredoxin

2 of 2

2.43

0.82

0.0320

PF01625

Peptide methionine sulfoxide reductase

2 of 2

2.43

0.82

0.0320

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node1	node2	node1 annotation	node2 annotation	score
GCA_000820765_00494	GCA_000820765_00495	Unannotated protein.	Unannotated protein.	0.538
GCA_000820765_00495	GCA_000820765_00494	Unannotated protein.	Unannotated protein.	0.538