STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
ITPA_PEDHCInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (190 aa)    
Predicted Functional Partners:
E0VAJ4_PEDHC
Adenine phosphoribosyltransferase, putative.
  
 0.981
E0VNC1_PEDHC
GMP synthase, putative.
  
 
 0.964
E0VM59_PEDHC
Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative.
  
 0.962
E0V8Z4_PEDHC
Nucleoside diphosphate kinase, putative; Belongs to the NDK family.
  
 
 0.961
E0VDW9_PEDHC
Nucleoside diphosphate kinase.
  
 
 0.960
E0VL28_PEDHC
Nucleoside diphosphate kinase.
  
 0.957
E0VL29_PEDHC
Nucleoside diphosphate kinase.
  
 0.957
E0VIY2_PEDHC
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
   
 0.955
E0VGF1_PEDHC
Guanylate kinase, putative.
  
 
 0.950
E0VDG2_PEDHC
Uncharacterized protein.
    
 0.949
Your Current Organism:
Pediculus humanus
NCBI taxonomy Id: 121224
Other names: P. humanus corporis, Pediculus humanus corporis, Pediculus humanus humanus, human body lice, human body louse
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