AFO51817.1 protein (Mycoplasma haemolamae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

AFO51817.1

Hypothetical protein. (189 aa)

Predicted Functional Partners:

AFO51815.1

0.773

AFO51816.1

0.773

AFO51818.1

0.773

AFO51814.1

0.578

AFO51819.1

0.551

AFO51820.1

0.551

AFO51821.1

0.551

AFO51822.1

0.551

AFO51811.1

0.463

AFO51812.1

0.463

Your Current Organism:

Mycoplasma haemolamae

NCBI taxonomy Id: 1212765
Other names: C. Mycoplasma haemolamae str. Purdue, Candidatus Mycoplasma haemolamae str. Purdue, Candidatus Mycoplasma haemolamae strain Purdue

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFO51811.1	AFO51812.1	MHLP_01155	MHLP_01160	Hypothetical protein.	Hypothetical protein.	0.773
AFO51811.1	AFO51814.1	MHLP_01155	MHLP_01170	Hypothetical protein.	Hypothetical protein.	0.608
AFO51811.1	AFO51815.1	MHLP_01155	MHLP_01175	Hypothetical protein.	Hypothetical protein.	0.463
AFO51811.1	AFO51816.1	MHLP_01155	MHLP_01180	Hypothetical protein.	Hypothetical protein.	0.463
AFO51811.1	AFO51817.1	MHLP_01155	MHLP_01185	Hypothetical protein.	Hypothetical protein.	0.463
AFO51811.1	AFO51818.1	MHLP_01155	MHLP_01190	Hypothetical protein.	Hypothetical protein.	0.463
AFO51812.1	AFO51811.1	MHLP_01160	MHLP_01155	Hypothetical protein.	Hypothetical protein.	0.773
AFO51812.1	AFO51814.1	MHLP_01160	MHLP_01170	Hypothetical protein.	Hypothetical protein.	0.608
AFO51812.1	AFO51815.1	MHLP_01160	MHLP_01175	Hypothetical protein.	Hypothetical protein.	0.463
AFO51812.1	AFO51816.1	MHLP_01160	MHLP_01180	Hypothetical protein.	Hypothetical protein.	0.463
AFO51812.1	AFO51817.1	MHLP_01160	MHLP_01185	Hypothetical protein.	Hypothetical protein.	0.463
AFO51812.1	AFO51818.1	MHLP_01160	MHLP_01190	Hypothetical protein.	Hypothetical protein.	0.463
AFO51814.1	AFO51811.1	MHLP_01170	MHLP_01155	Hypothetical protein.	Hypothetical protein.	0.608
AFO51814.1	AFO51812.1	MHLP_01170	MHLP_01160	Hypothetical protein.	Hypothetical protein.	0.608
AFO51814.1	AFO51815.1	MHLP_01170	MHLP_01175	Hypothetical protein.	Hypothetical protein.	0.578
AFO51814.1	AFO51816.1	MHLP_01170	MHLP_01180	Hypothetical protein.	Hypothetical protein.	0.578
AFO51814.1	AFO51817.1	MHLP_01170	MHLP_01185	Hypothetical protein.	Hypothetical protein.	0.578
AFO51814.1	AFO51818.1	MHLP_01170	MHLP_01190	Hypothetical protein.	Hypothetical protein.	0.578
AFO51814.1	AFO51819.1	MHLP_01170	MHLP_01195	Hypothetical protein.	Hypothetical protein.	0.423
AFO51814.1	AFO51820.1	MHLP_01170	MHLP_01200	Hypothetical protein.	Hypothetical protein.	0.423

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.903

expected number of edges:

20

PPI enrichment p-value:

7.5e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006544

Glycine metabolic process

5 of 6

2.32

3.4

1.82e-07

GO:0006546

Glycine catabolic process

4 of 4

2.4

2.89

2.75e-06

GO:0009069

Serine family amino acid metabolic process

6 of 23

1.82

2.81

1.97e-07

GO:1901605

Alpha-amino acid metabolic process

8 of 120

1.23

1.55

9.37e-07

GO:0046653

Tetrahydrofolate metabolic process

3 of 10

1.88

1.48

0.0010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

5 of 8

2.2

3.22

2.81e-07

GO:0004047

Aminomethyltransferase activity

2 of 2

2.4

0.94

0.0190

GO:0019238

Cyclohydrolase activity

2 of 5

2.0

0.7

0.0496

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005960

Glycine cleavage complex

2 of 2

2.4

1.35

0.0032

GO:1990204

Oxidoreductase complex

3 of 26

1.46

1.06

0.0038

GO:0005829

Cytosol

7 of 297

0.78

0.59

0.0032

GO:0005737

Cytoplasm

11 of 1064

0.42

0.34

0.0032

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1597

Glycine metabolic process

4 of 5

2.31

2.97

1.47e-06

CL:1576

GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1, and Glycine metabolic process

5 of 16

1.9

2.74

6.83e-07

CL:1575

Mixed, incl. GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1, and Oxidoreductase activity, acting on the CH-NH2 group of donors

6 of 26

1.77

2.72

1.94e-07

CL:1569

Mixed, incl. FAD/NAD(P)-binding domain superfamily, and Glycine metabolic process

7 of 47

1.58

2.4

1.34e-07

CL:1565

Cellular amino acid metabolic process, and FAD/NAD(P)-binding domain superfamily

8 of 187

1.03

1.14

4.76e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

6 of 21

1.86

3.16

2.37e-08

map00260

Glycine, serine and threonine metabolism

6 of 56

1.43

1.87

2.33e-06

map00630

Glyoxylate and dicarboxylate metabolism

5 of 52

1.39

1.57

2.92e-05

map01200

Carbon metabolism

7 of 107

1.22

1.49

2.33e-06

map01110

Biosynthesis of secondary metabolites

9 of 344

0.82

0.8

9.59e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005960

Glycine cleavage complex

4 of 5

2.31

2.74

4.66e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08669

Glycine cleavage T-protein C-terminal barrel domain

3 of 7

2.03

1.35

0.0024

PF01571

Aminomethyltransferase folate-binding domain

3 of 8

1.98

1.34

0.0024

PF01212

Beta-eliminating lyase

2 of 5

2.0

0.73

0.0438

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029043

Glycine cleavage T-protein/YgfZ, C-terminal

3 of 6

2.1

1.23

0.0046

IPR028896

Aminomethyltransferase-like

3 of 6

2.1

1.23

0.0046

IPR013977

Glycine cleavage T-protein, C-terminal barrel domain

3 of 6

2.1

1.23

0.0046

IPR006222

Aminomethyltransferase, folate-binding domain

3 of 6

2.1

1.23

0.0046

IPR027266

GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1

3 of 10

1.88

1.18

0.0046

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