STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A0G2FUG2Putative hypoxanthine guanine phosphoribosyltransferase. (212 aa)    
Predicted Functional Partners:
A0A0G2FPD1
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 
 0.901
A0A0G2FLV6
Putative adenine phosphoribosyltransferase.
  
 0.877
A0A0G2I743
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
  
 
 0.872
A0A0G2H9Z1
Putative amp deaminase 2.
  
 0.844
A0A0G2HZ66
Putative bifunctional purine biosynthesis protein.
    
 0.830
A0A0G2HXJ0
Putative phosphoribosyl transferase domain protein.
  
 0.827
A0A0G2HQL8
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.826
A0A0G2IF31
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.826
A0A0G2FFT2
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 
  0.812
A0A0G2H5V5
Uncharacterized protein.
   
 0.812
Your Current Organism:
Diaporthe ampelina
NCBI taxonomy Id: 1214573
Other names: CBS 114016, D. ampelina, Diaporthe ampelina (Berk. & M.A. Curtis) R.R. Gomes, C. Glienke & Crous, Diaporthe neoviticola, Diaporthe sp. DU-2012e, Fusicoccum viticolum, Phoma ampelina, Phoma viticola, Phomopsis ampelina, Phomopsis sp. Pho06, Phomopsis sp. Pho07, Phomopsis sp. Pho10, Phomopsis sp. Pho16, Phomopsis sp. Pho18, Phomopsis sp. Pho24, Phomopsis sp. Pho25, Phomopsis sp. Pho26, Phomopsis sp. Pho28, Phomopsis sp. Pho32, Phomopsis sp. PhoCT1L, Phomopsis sp. taxon 2, Phomopsis viticola, STEU 2660
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.