A0A0G2IFJ1 protein (Diaporthe ampelina) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A0G2IFJ1

Uncharacterized protein. (207 aa)

Predicted Functional Partners:

A0A0G2FJJ0

0.575

A0A0G2HTV5

0.564

A0A0G2HG60

0.488

A0A0G2FD61

0.454

A0A0G2HYW2

0.454

A0A0G2FDX6

0.439

A0A0G2FP00

0.434

A0A0G2I9H3

0.434

A0A0G2FFC7

0.422

A0A0G2HDL8

0.422

Your Current Organism:

Diaporthe ampelina

NCBI taxonomy Id: 1214573
Other names: CBS 114016, D. ampelina, Diaporthe ampelina (Berk. & M.A. Curtis) R.R. Gomes, C. Glienke & Crous, Diaporthe neoviticola, Diaporthe sp. DU-2012e, Fusicoccum viticolum, Phoma ampelina, Phoma viticola, Phomopsis ampelina, Phomopsis sp. Pho06, Phomopsis sp. Pho07, Phomopsis sp. Pho10, Phomopsis sp. Pho16, Phomopsis sp. Pho18, Phomopsis sp. Pho24, Phomopsis sp. Pho25, Phomopsis sp. Pho26, Phomopsis sp. Pho28, Phomopsis sp. Pho32, Phomopsis sp. PhoCT1L, Phomopsis sp. taxon 2, Phomopsis viticola, STEU 2660

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0G2FD61	A0A0G2HG60	Putative urea amidolyase.	Putative amidase-like protein.	0.570
A0A0G2FD61	A0A0G2HYW2	Putative urea amidolyase.	Putative urea amidolyase.	0.845
A0A0G2FD61	A0A0G2IFJ1	Putative urea amidolyase.	Uncharacterized protein.	0.454
A0A0G2FDX6	A0A0G2IFJ1	Putative mrg15 protein.	Uncharacterized protein.	0.439
A0A0G2FFC7	A0A0G2FJJ0	Putative 26s proteasome regulatory subunit rpn11.	Putative ankyrin repeat-containing protein.	0.566
A0A0G2FFC7	A0A0G2FP00	Putative 26s proteasome regulatory subunit rpn11.	Uncharacterized protein.	0.753
A0A0G2FFC7	A0A0G2HTV5	Putative 26s proteasome regulatory subunit rpn11.	ANK_REP_REGION domain-containing protein.	0.611
A0A0G2FFC7	A0A0G2I9H3	Putative 26s proteasome regulatory subunit rpn11.	Putative e3 ubiquitin ligase complex scf subunit scon-3; Belongs to the SKP1 family.	0.753
A0A0G2FFC7	A0A0G2IFJ1	Putative 26s proteasome regulatory subunit rpn11.	Uncharacterized protein.	0.422
A0A0G2FJJ0	A0A0G2FFC7	Putative ankyrin repeat-containing protein.	Putative 26s proteasome regulatory subunit rpn11.	0.566
A0A0G2FJJ0	A0A0G2FP00	Putative ankyrin repeat-containing protein.	Uncharacterized protein.	0.849
A0A0G2FJJ0	A0A0G2HDL8	Putative ankyrin repeat-containing protein.	Uncharacterized protein.	0.566
A0A0G2FJJ0	A0A0G2HG60	Putative ankyrin repeat-containing protein.	Putative amidase-like protein.	0.864
A0A0G2FJJ0	A0A0G2HTV5	Putative ankyrin repeat-containing protein.	ANK_REP_REGION domain-containing protein.	0.956
A0A0G2FJJ0	A0A0G2I9H3	Putative ankyrin repeat-containing protein.	Putative e3 ubiquitin ligase complex scf subunit scon-3; Belongs to the SKP1 family.	0.849
A0A0G2FJJ0	A0A0G2IFJ1	Putative ankyrin repeat-containing protein.	Uncharacterized protein.	0.575
A0A0G2FP00	A0A0G2FFC7	Uncharacterized protein.	Putative 26s proteasome regulatory subunit rpn11.	0.753
A0A0G2FP00	A0A0G2FJJ0	Uncharacterized protein.	Putative ankyrin repeat-containing protein.	0.849
A0A0G2FP00	A0A0G2HDL8	Uncharacterized protein.	Uncharacterized protein.	0.753
A0A0G2FP00	A0A0G2HTV5	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.917

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

7.7e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090114

COPII-coated vesicle budding

4 of 17

2.75

3.44

4.11e-07

GO:0030203

Glycosaminoglycan metabolic process

3 of 13

2.74

2.38

4.24e-05

GO:0090110

COPII-coated vesicle cargo loading

2 of 13

2.57

1.15

0.0078

GO:0006886

Intracellular protein transport

4 of 493

1.29

0.79

0.0142

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0102148

N-acetyl-beta-D-galactosaminidase activity

3 of 4

3.26

2.99

3.84e-06

GO:0004563

beta-N-acetylhexosaminidase activity

3 of 4

3.26

2.99

3.84e-06

GO:0004197

Cysteine-type endopeptidase activity

3 of 89

1.91

1.25

0.0034

GO:0005198

Structural molecule activity

4 of 497

1.29

0.77

0.0155

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030127

COPII vesicle coat

4 of 20

2.68

3.65

1.40e-07

GO:0031080

Nuclear pore outer ring

2 of 7

2.84

1.9

0.00034

GO:0005764

Lysosome

3 of 83

1.94

1.71

0.00034

GO:0070971

Endoplasmic reticulum exit site

2 of 22

2.34

1.44

0.0021

GO:0005615

Extracellular space

3 of 139

1.71

1.38

0.0012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23813

COPII-coated vesicle budding

4 of 17

2.75

3.41

4.57e-07

CL:38623

Peptidase C1A, and Peptidase family A1 domain

4 of 75

2.11

2.32

2.27e-05

CL:38637

Mixed, incl. Peptidase C1A, and Saposin-like

3 of 49

2.17

1.83

0.00029

CL:23833

COPII-coated vesicle budding

2 of 5

2.98

1.75

0.00068

CL:23818

Sec24-like, trunk domain, and Protein transport protein SEC31-like

2 of 5

2.98

1.75

0.00068

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

3 of 16

2.65

2.74

7.93e-06

map00604

Glycosphingolipid biosynthesis - ganglio series

3 of 21

2.54

2.71

8.27e-06

map00531

Glycosaminoglycan degradation

3 of 42

2.23

2.27

3.85e-05

map00511

Other glycan degradation

3 of 43

2.22

2.27

3.85e-05

map00513

Various types of N-glycan biosynthesis

3 of 58

2.09

2.13

5.83e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2024101

CS/DS degradation

3 of 4

3.26

3.21

1.53e-06

MAP-2160916

Hyaluronan uptake and degradation

3 of 5

3.16

3.2

1.53e-06

MAP-2142845

Hyaluronan metabolism

3 of 6

3.08

3.2

1.53e-06

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

3 of 13

2.74

2.82

6.12e-06

MAP-2022857

Keratan sulfate degradation

3 of 19

2.58

2.65

1.12e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1905379

beta-N-acetylhexosaminidase complex

2 of 3

3.2

1.5

0.0020

GOCC:0031080

Nuclear pore outer ring

2 of 8

2.78

1.29

0.0045

GOCC:0070971

Endoplasmic reticulum exit site

2 of 11

2.64

1.25

0.0052

GOCC:0030134

COPII-coated ER to Golgi transport vesicle

2 of 22

2.34

1.01

0.0137

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 214

1.65

1.51

0.00043

KW-0788

Thiol protease

2 of 46

2.02

0.84

0.0266

KW-0378

Hydrolase

5 of 1524

0.9

0.53

0.0266

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00728

Glycosyl hydrolase family 20, catalytic domain

3 of 4

3.26

3.0

3.75e-06

PF14845

Beta-acetyl hexosaminidase like

2 of 3

3.2

1.55

0.0016

PF12931

Sec23-binding domain of Sec16

2 of 4

3.08

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025705

Beta-hexosaminidase

3 of 4

3.26

2.74

1.10e-05

IPR015883

Glycoside hydrolase family 20, catalytic domain

3 of 4

3.26

2.74

1.10e-05

IPR040251

Protein transport protein SEC31-like

2 of 2

3.38

1.59

0.0014

IPR013201

Cathepsin propeptide inhibitor domain (I29)

3 of 39

2.27

1.55

0.0012

IPR037363

Sec13/Seh1 family

2 of 3

3.2

1.51

0.0019

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00848

Cathepsin propeptide inhibitor domain (I29)

3 of 39

2.27

1.85

0.00030

SM00320

WD40 repeats

4 of 236

1.61

1.45

0.00051

SM00645

Papain family cysteine protease

2 of 34

2.15

0.96

0.0161

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