STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103524369Exonuclease 3'-5' domain-containing protein 2. (537 aa)    
Predicted Functional Partners:
LOC103515320
Exonuclease 1.
   
 0.867
LOC103514694
Replication protein A 14 kDa subunit-like.
    
 0.841
LOC113465757
Replication protein A 14 kDa subunit-like.
    
 0.841
LOC103513643
Nibrin.
    
 0.772
LOC113471786
BRCA1-associated RING domain protein 1-like isoform X1.
    
 0.766
LOC103519880
Uncharacterized protein LOC103519880.
    
 0.766
LOC103514758
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.759
LOC103510353
Uncharacterized protein LOC103510353.
   
 0.750
LOC103512944
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.750
LOC103510039
DNA replication ATP-dependent helicase/nuclease DNA2.
     
 0.737
Your Current Organism:
Diaphorina citri
NCBI taxonomy Id: 121845
Other names: Asian citrus psyllid, D. citri
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.