STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (402 aa)    
Predicted Functional Partners:
EME97139.1
Exodeoxyribonuclease; COG0708 Exonuclease III.
 
 0.982
EMF02035.1
COG0708 Exonuclease III.
  
 0.888
nfo
Apurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
 
 0.827
EMF01948.1
Transcriptional regulator; COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases.
 
     0.780
EMF01950.1
NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes.
       0.776
EME98325.1
COG1194 A/G-specific DNA glycosylase.
 
 
0.775
EMF01951.1
COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.
   
   0.726
mutM
Formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.719
EME97176.1
Endonuclease VIII and DNA N-glycosylase with an AP lyase activity; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family.
   
  
 0.696
EME96825.1
H2TH DNA-binding DNA glycosylase/AP lyase; COG0266 Formamidopyrimidine-DNA glycosylase.
   
  
 0.696
Your Current Organism:
Streptomyces mobaraensis
NCBI taxonomy Id: 1223523
Other names: S. mobaraensis NBRC 13819 = DSM 40847, Streptomyces mobaraensis ATCC 29032, Streptomyces mobaraensis DSM 40847, Streptomyces mobaraensis DSM 40847 = NBRC 13819, Streptomyces mobaraensis IFO 13819, Streptomyces mobaraensis NBRC 13819, Streptomyces mobaraensis NBRC 13819 = DSM 40847, Streptomyces mobaraensis NRRL B-3729
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