Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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NMB0081dTDP-4-keto-6-deoxy-D-glucose-3,6-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa)    
Predicted Functional Partners:
NMB0756
Putative dTDP-L-rhamnose synthase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family.
 
 0.999
rfbB-1
dTDP-D-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
 
 
 0.985
rfbA-2
Glucose-1-phosphate thymidylyltransferase; Identified by similarity to EGAD:23719; match to protein family HMM PF00483; match to protein family HMM TIGR01207.
 
  
 0.961
NMB1818
Putative lipopolysaccharide biosynthesis protein; Identified by similarity to EGAD:165571; match to protein family HMM PF01943.
  
  
 0.939
rfbB-2
dTDP-D-glucose 4,6-dehydratase; Identified by similarity to EGAD:40672; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01181.
 
  
 0.925
rfbA-1
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis; Belongs to the glucose-1-phosphate thymidylyltransferase family.
 
  
 0.899
murU
Mannose-1-phosphate guanyltransferase-related protein; Catalyzes the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P. Is likely involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc. Is able to complement the fosfomycin sensitivity phenotype of a P.putida mutant lacking murU.
  
  
 0.869
NMB1359
Putative CDP-6-deoxy-delta-3,4-glucoseen reductase; Identified by similarity to EGAD:21136; match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF08030.
  
    0.777
lipA
Capsule polysaccharide modification protein LipA; Involved in the phospholipid modification of the capsular polysaccharide, a strong requirement for its translocation to the cell surface.
  
    0.715
pglB
Pilin glycosylation protein PglB; Identified by similarity to GB:3299889; match to protein family HMM PF00132; match to protein family HMM PF02397.
  
  
 0.699
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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