Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smgPutative smg protein; Identified by similarity to EGAD:6532; match to protein family HMM PF04361; Belongs to the Smg family. (153 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.899
dprA
DNA processing chain A; Identified by similarity to EGAD:27998; match to protein family HMM PF02481; match to protein family HMM TIGR00732.
     
 0.869
NMB0800
Conserved hypothetical protein; Identified by similarity to EGAD:133408; match to protein family HMM PF01985; match to protein family HMM TIGR00253.
      
 0.772
NMB0454
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.743
NMB0113
Hypothetical protein; Identified by Glimmer2; putative.
 
    0.734
NMB1681
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.731
NMB1954
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.693
NMB0114
Putative nitrogen regulation protein NtrY; Identified by similarity to EGAD:163355; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
    0.660
ntrX
Nitrogen assimilation regulatory protein NtrX; Identified by similarity to EGAD:5624; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM TIGR01199.
 
     0.654
NMB1227
Conserved hypothetical protein; Identified by similarity to EGAD:132841; match to protein family HMM PF04635.
  
     0.654
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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