Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity). Belongs to the MinC family. (237 aa)    
Predicted Functional Partners:
minD
Septum site-determining protein MinD; ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity); Belongs to the ParA family. MinD subfamily.
 
 
 0.999
minE
Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity).
 
  
 0.947
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
   
 
 0.921
NMB0173
Transcriptional regulator, LysR family; Identified by similarity to EGAD:137604; match to protein family HMM PF00126; match to protein family HMM PF03466; Belongs to the LysR transcriptional regulatory family.
     
 0.747
NMB0191
ParA family protein; Identified by similarity to EGAD:5746; match to protein family HMM PF01656.
   
  
 0.639
rplQ
50S ribosomal protein L17; Identified by similarity to EGAD:19865; match to protein family HMM PF01196; match to protein family HMM TIGR00059.
  
    0.598
ispA
Geranyltranstransferase; Identified by similarity to EGAD:28427; match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family.
   
  
 0.530
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.514
nuoE
NADH dehydrogenase I, E subunit; Identified by similarity to EGAD:102345; match to protein family HMM PF01257; match to protein family HMM TIGR01958.
      
 0.503
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
 
     0.467
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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