Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
kefBGlutathione-regulated potassium-efflux system protein; Identified by similarity to EGAD:29394; match to protein family HMM PF02080; match to protein family HMM PF02254; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (658 aa)    
Predicted Functional Partners:
NMB0977
Putative modulator of drug activity B; Identified by similarity to EGAD:90558; match to protein family HMM PF02525.
  
 
 0.898
mdaB
Modulator of drug activity B; Identified by similarity to EGAD:90558; match to protein family HMM PF02525.
  
 
 0.898
fabI
Enoyl-(acyl-carrier-protein) reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
     
 0.816
htrA
Protease DO; Identified by similarity to EGAD:16686; match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.
     
 0.692
trkA
Trk system potassium uptake protein TrkA; Identified by similarity to EGAD:16153; match to protein family HMM PF02080; match to protein family HMM PF02254.
     
 0.672
NMB0716
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.627
pilB
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
  
  
 0.620
ribA/B
GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family.
   
 
 0.617
NMB0217
Putative RNA polymerase sigma-54 factor RpoN; Identified by similarity to EGAD:7711; match to protein family HMM PF00309; match to protein family HMM PF04552; match to protein family HMM PF04963.
     
 0.615
NMB0581
Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.
  
  
 0.595
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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