| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aldA | gloA | NMB1968 | NMB0340 | Aldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | 0.905 |
| aldA | ilvA | NMB1968 | NMB0878 | Aldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.822 |
| aldA | sdaA | NMB1968 | NMB0211 | Aldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | L-serine dehydratase; Identified by similarity to GP:3402236; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.810 |
| aldA | trpA | NMB1968 | NMB0678 | Aldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.812 |
| aldA | trpB | NMB1968 | NMB0699 | Aldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.804 |
| cysE | glyA | NMB0560 | NMB1055 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.867 |
| cysE | ilvA | NMB0560 | NMB0878 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.826 |
| cysE | metM | NMB0560 | NMB1228 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Homoserine dehydrogenase; Identified by similarity to EGAD:6746; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.823 |
| cysE | pssA | NMB0560 | NMB1318 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | CDP-diacylglycerol--serine O-phosphatidyltransferse; Identified by similarity to EGAD:166539; match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.800 |
| cysE | sdaA | NMB0560 | NMB0211 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | L-serine dehydratase; Identified by similarity to GP:3402236; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.934 |
| cysE | serB | NMB0560 | NMB0981 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Phosphoserine phosphatase; Identified by similarity to EGAD:8936; match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.829 |
| cysE | trpA | NMB0560 | NMB0678 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.800 |
| cysE | trpB | NMB0560 | NMB0699 | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.803 |
| gloA | aldA | NMB0340 | NMB1968 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Aldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | 0.905 |
| gloA | ilvA | NMB0340 | NMB0878 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.806 |
| gloA | sdaA | NMB0340 | NMB0211 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | L-serine dehydratase; Identified by similarity to GP:3402236; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.801 |
| gloA | trpA | NMB0340 | NMB0678 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.800 |
| gloA | trpB | NMB0340 | NMB0699 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.815 |
| glyA | cysE | NMB1055 | NMB0560 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine acetyltransferase; Identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | 0.867 |
| glyA | ilvA | NMB1055 | NMB0878 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.947 |
