Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. (794 aa)    
Predicted Functional Partners:
pdhA
Pyruvate dehydrogenase, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.948
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.945
sfcA
Malate oxidoreductase (NAD); Identified by similarity to GP:1799887; match to protein family HMM PF00390; match to protein family HMM PF03949.
   
 
 0.934
pykA
Pyruvate kinase II; Identified by similarity to EGAD:21471; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family.
     
 0.933
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.933
lldD
L-lactate dehydrogenase; Identified by similarity to GP:4761135; match to protein family HMM PF01070.
     
 0.927
ldhA
D-lactate dehydrogenase; Identified by similarity to EGAD:28739; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.911
dld
D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.
    
 0.905
pgi-2
Glucose-6-phosphate isomerase; Identified by similarity to EGAD:90386; match to protein family HMM PF00342.
    
 0.905
aldA
Aldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family.
     
 0.905
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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