Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NMB0786Conserved hypothetical protein; Identified by similarity to EGAD:91404; match to protein family HMM PF04261; match to protein family HMM TIGR01413. (302 aa)    
Predicted Functional Partners:
NMB0036
Conserved hypothetical protein; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family.
  
   
 0.646
NMB0035
Conserved hypothetical protein; Identified by similarity to EGAD:90734; match to protein family HMM PF04302; Belongs to the EfeM/EfeO family.
 
  
 0.620
NMB1557
Conserved hypothetical protein; Identified by similarity to EGAD:156049; match to protein family HMM PF04314.
  
    0.577
recB
Exodeoxyribonuclease V 135 KD polypeptide; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination a [...]
       0.558
atpF
ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
   
  
 0.513
NMB1221
Hypothetical protein; Identified by Glimmer2; putative.
      
 0.502
hisS-1
histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
      
 0.484
NMB1844
Hypothetical protein; Identified by Glimmer2; putative.
      
 0.479
NMB1746
Hypothetical protein; Identified by Glimmer2; putative.
      
 0.478
NMB0784
Putative phage shock protein E precursor; Identified by similarity to EGAD:6573; match to protein family HMM PF00581.
       0.477
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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