Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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cysI-2Sulfite reductase hemoprotein, beta-component; Identified by similarity to EGAD:21188; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM TIGR02041. (589 aa)    
Predicted Functional Partners:
cysJ-2
Sulfite reductase (NADPH) flavoprotein, alpha component; Identified by similarity to EGAD:22695; match to protein family HMM PF00175; match to protein family HMM PF00258; match to protein family HMM PF00667; match to protein family HMM TIGR01931.
 
 0.985
cysJ-1
Sulfite reductase (NADPH) flavoprotein, alpha component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
 
 0.954
cysG-2
Siroheme synthase; Identified by similarity to EGAD:142433; match to protein family HMM PF00590; match to protein family HMM TIGR01469; match to protein family HMM TIGR01470.
 
  
 0.954
cysG-1
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
 0.913
cysN-2
Sulfate adenylyltransferase, subunit 1; Identified by similarity to EGAD:18882; match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR02034.
  
  
 0.903
cysD-2
Sulfate adenylyltransferase, subunit 2; Identified by similarity to EGAD:46109; match to protein family HMM PF01507; match to protein family HMM TIGR02039.
  
  
 0.869
cysH-2
Phosphoadenosine phosphosulfate reductase; Identified by similarity to EGAD:151586; match to protein family HMM PF01507; match to protein family HMM TIGR02055.
 
  
 0.869
cysA
Sulfate ABC transporter, ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
  
  
 0.806
cysH-1
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.749
cysW
Sulfate ABC transporter, permease protein; Identified by similarity to EGAD:49750; match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02140.
  
  
 0.745
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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