Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NMB1309Putative fimbrial biogenesis and twitching motility protein; Identified by similarity to EGAD:39885; match to protein family HMM PF00515; match to protein family HMM TIGR02521. (253 aa)    
Predicted Functional Partners:
pilO
pilO protein; Identified by similarity to GP:1914829; match to protein family HMM PF04350.
  
   
 0.864
pilM
pilM protein; Identified by similarity to EGAD:151887; match to protein family HMM TIGR01175.
  
   
 0.845
pilN
pilN protein; Identified by similarity to EGAD:151888; match to protein family HMM PF05137.
  
  
 0.839
pilQ
pilQ protein; Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA (By similarity); Belongs to the bacterial secretin family. PilQ subfamily.
  
   
 0.833
rlmN
Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.
  
    0.821
pilP
pilP protein; Identified by similarity to EGAD:40689; match to protein family HMM PF04351.
  
   
 0.815
gcpE
gcpE protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
    0.777
NMB0109
Conserved hypothetical protein; Identified by similarity to EGAD:109565; match to protein family HMM PF01476.
  
     0.751
NMB0770
Putative type IV pilus assembly protein PilZ; Identified by similarity to EGAD:38751; match to protein family HMM PF07238.
  
   
 0.722
NMB2016
Type IV pilin-related protein; Identified by similarity to GP:2073462; match to protein family HMM PF07963; match to protein family HMM TIGR02532.
  
  
 0.704
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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