Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lbpALactoferrin-binding protein A; Unknown. May be an iron-siderophore receptor. (943 aa)    
Predicted Functional Partners:
lbpB
Identified by similarity to GP:3582728; match to protein family HMM PF01298.
  
  
 0.971
tonB
TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence.
 
 
 0.897
fbpA
iron(III) ABC transporter, periplasmic binding protein; This protein may be a central component in the iron- acquisition system.
  
  
 0.870
tbp2
Transferrin-binding protein 2; Acts as a transferrin receptor and is required for transferrin utilization.
   
  
 0.826
NMB0313
Conserved hypothetical protein; Identified by similarity to GP:3523136; match to protein family HMM PF04575; match to protein family HMM PF07719.
  
    0.824
NMB0572
Hypothetical protein; Identified by Glimmer2; putative.
   
    0.800
lgtB
lacto-N-neotetraose biosynthesis glycosyl transferase LgtB; Adds the second galactose to the lacto-N-tetraose chain in lipooligosaccharide (LOS).
  
   
 0.789
lgtE
lacto-N-neotetraose biosynthesis glycosyl transferase LgtE; Adds the first galactose to the lacto-N-tetraose chain in lipooligosaccharide (LOS).
  
   
 0.772
NMB1645
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.761
NMB1551
Conserved hypothetical protein; Identified by similarity to GP:3402502; match to protein family HMM PF05707.
  
     0.755
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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