STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ponAPenicillin-binding protein 1; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (798 aa)    
Predicted Functional Partners:
NMB0877
Penicillin-binding protein; Identified by similarity to EGAD:10529; match to protein family HMM PF00768; match to protein family HMM PF07943; Belongs to the peptidase S11 family.
     
 0.909
ftsW
Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.
  
   
 0.856
pilQ
pilQ protein; Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA (By similarity); Belongs to the bacterial secretin family. PilQ subfamily.
  
  
 0.810
parC
Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
   
  
 0.727
mtrR
Trancscriptional regulator MtrR; Identified by similarity to EGAD:19994; match to protein family HMM PF00440.
      
 0.726
porB
Major outer membrane protein PIB; Serves as a slightly cation selective porin; Belongs to the Gram-negative porin family.
   
  
 0.724
penA
Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
  
 
 
0.714
pilM
pilM protein; Identified by similarity to EGAD:151887; match to protein family HMM TIGR01175.
 
    0.694
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.675
NMB0315
Conserved hypothetical protein; Identified by similarity to GP:146890; match to protein family HMM PF01551.
  
  
 0.668
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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