Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lgtAlacto-N-neotetraose biosynthesis glycosyl transferase LgtA; Identified by similarity to EGAD:40824; match to protein family HMM PF00535. (349 aa)    
Predicted Functional Partners:
lgtB
lacto-N-neotetraose biosynthesis glycosyl transferase LgtB; Adds the second galactose to the lacto-N-tetraose chain in lipooligosaccharide (LOS).
  
  
 0.919
lgtE
lacto-N-neotetraose biosynthesis glycosyl transferase LgtE; Adds the first galactose to the lacto-N-tetraose chain in lipooligosaccharide (LOS).
  
  
 0.864
galE
UDP-glucose 4-epimerase; Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
 
  
 0.779
lgtF
Beta-1,4-glucosyltransferase; Identified by similarity to EGAD:124882; match to protein family HMM PF00535.
 
   
 0.755
glyS
glycyl-tRNA synthetase, beta chain; Identified by similarity to EGAD:9635; match to protein family HMM PF02092; match to protein family HMM PF05746; match to protein family HMM TIGR00211.
       0.737
pglB
Pilin glycosylation protein PglB; Identified by similarity to GB:3299889; match to protein family HMM PF00132; match to protein family HMM PF02397.
 
  
 0.725
lst
Alpha-2,3-sialyltransferase; Catalyzes the transfer of sialic acid from the substrate CMP- N-acetylneuraminate to the terminal galactose residue of the lacto-N- neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage. Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N.meningitidis from complement-mediated serum killing and from phagocytic killing by neutrophils. In vitro, can use a number of different synthetic acceptors with lactose or galactose as the saccharide portion, but sho [...]
     
 0.707
rfaK
alpha-1,2-N-acetylglucosamine transferase; Identified by similarity to EGAD:40699; match to protein family HMM PF00534.
 
  
 0.589
pglA
Glycosyltransferase; Identified by similarity to GP:3599932; match to protein family HMM PF00534.
  
  
 0.542
NMB1931
Hypothetical protein; Identified by Glimmer2; putative.
       0.530
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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