Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aldAAldehyde dehydrogenase A; Identified by similarity to EGAD:21715; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. (480 aa)    
Predicted Functional Partners:
sfcA
Malate oxidoreductase (NAD); Identified by similarity to GP:1799887; match to protein family HMM PF00390; match to protein family HMM PF03949.
   
 0.931
pykA
Pyruvate kinase II; Identified by similarity to EGAD:21471; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family.
   
 0.924
hprA
Glycerate dehydrogenase; Identified by similarity to EGAD:28541; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 
 0.922
lldD
L-lactate dehydrogenase; Identified by similarity to GP:4761135; match to protein family HMM PF01070.
   
 
 0.906
gloA
Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
   
 0.905
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
     
 0.905
ldhA
D-lactate dehydrogenase; Identified by similarity to EGAD:28739; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 
 0.904
dld
D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.
     
 0.900
pdhA
Pyruvate dehydrogenase, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
  0.900
NMB1830
Putative phosphoglycolate phosphatase; Identified by similarity to EGAD:13772; match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549.
     
  0.900
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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