STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnBNitrogen regulatory protein P-II; Identified by similarity to EGAD:7369; match to protein family HMM PF00543; Belongs to the P(II) protein family. (112 aa)    
Predicted Functional Partners:
NMB0615
Putative ammonium transporter AmtB; Identified by similarity to GP:3136068; match to protein family HMM PF00909; match to protein family HMM TIGR00836.
 
 0.999
glnD
protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
 
 0.990
argA
N-acetylglutamate synthase; Identified by similarity to EGAD:10737; match to protein family HMM PF00583; match to protein family HMM PF00696; match to protein family HMM TIGR01890; Belongs to the acetyltransferase family. ArgA subfamily.
   
 
 0.835
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.827
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
   
 
 0.824
NMB1606
Sensor histidine kinase; Identified by similarity to EGAD:152602; match to protein family HMM PF00512.
  
 
 0.769
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
 
 0.728
glnA
Glutamate--ammonia ligase; Identified by similarity to EGAD:130497; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653.
 
  
 0.650
NMB1955
Cadmium resistance protein; Identified by similarity to GP:1916729; match to protein family HMM PF03596; match to protein family HMM TIGR00779.
      
 0.599
NMB1993
iron(III) ABC transporter, ATP-binding protein; Identified by similarity to EGAD:108972; match to protein family HMM PF00005.
      
 0.599
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.