Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ligA-2DNA ligase; Identified by similarity to EGAD:28195; match to protein family HMM PF01068. (274 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.948
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.946
NMB0769
Putative DNA polymerase III, delta prime subunit; Identified by similarity to GP:145799; match to protein family HMM TIGR00678.
   
 0.725
gmhB
Putative histidinol-phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. Belongs to the GmhB family.
   
 0.659
NMB2047
Putative hypoxanthine-guanine phosphoribosyltransferase; Identified by similarity to EGAD:77860; match to protein family HMM PF00156.
       0.578
NMB2049
Glyoxalase II family protein; Identified by similarity to EGAD:91564; match to protein family HMM PF00753.
  
    0.571
ruvC
Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
      
 0.533
NMB2046
PTS system, IIAB component; Identified by similarity to EGAD:24904; match to protein family HMM PF03610.
       0.455
xthA
Exodeoxyribonuclease III; Identified by similarity to EGAD:104607; match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633.
  
 
 0.452
exoA
Exodeoxyribonuclease; Identified by similarity to EGAD:19899; match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633.
  
 
 0.452
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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