SFQ79352.1 protein (Siccationidurans arizonensis)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SFQ79352.1

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains. (215 aa)

Predicted Functional Partners:

SFQ51536.1

0.974

SFQ51352.1

0.973

SFP79979.1

0.971

SFP68701.1

0.920

SFQ22908.1

0.920

SFQ52148.1

0.920

SFQ67487.1

0.920

SFQ76515.1

0.920

SFQ77087.1

0.920

SFQ05490.1

0.897

Your Current Organism:

Siccationidurans arizonensis

NCBI taxonomy Id: 1227077
Other names: DSM 17870, Hymenobacter arizonensis, Hymenobacter arizonensis Reddy and Garcia-Pichel 2013, Hymenobacter sp. OR362-8, JCM 13504, S. arizonensis, strain OR362-8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFP68701.1	SFP79979.1	SAMN04515668_0019	SAMN04515668_0387	PAS domain S-box-containing protein.	Methyl-accepting chemotaxis protein.	0.999
SFP68701.1	SFQ05490.1	SAMN04515668_0019	SAMN04515668_1290	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.973
SFP68701.1	SFQ22908.1	SAMN04515668_0019	SAMN04515668_1478	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SFP68701.1	SFQ51352.1	SAMN04515668_0019	SAMN04515668_2704	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SFP68701.1	SFQ51536.1	SAMN04515668_0019	SAMN04515668_2719	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SFP68701.1	SFQ52148.1	SAMN04515668_0019	SAMN04515668_2764	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SFP68701.1	SFQ67487.1	SAMN04515668_0019	SAMN04515668_3632	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SFP68701.1	SFQ76515.1	SAMN04515668_0019	SAMN04515668_4220	PAS domain S-box-containing protein.	Signal transduction histidine kinase.	0.999
SFP68701.1	SFQ77087.1	SAMN04515668_0019	SAMN04515668_4275	PAS domain S-box-containing protein.	Hpt domain-containing protein.	0.999
SFP68701.1	SFQ79352.1	SAMN04515668_0019	SAMN04515668_4431	PAS domain S-box-containing protein.	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	0.920
SFP79979.1	SFP68701.1	SAMN04515668_0387	SAMN04515668_0019	Methyl-accepting chemotaxis protein.	PAS domain S-box-containing protein.	0.999
SFP79979.1	SFQ05490.1	SAMN04515668_0387	SAMN04515668_1290	Methyl-accepting chemotaxis protein.	PAS domain S-box-containing protein.	0.999
SFP79979.1	SFQ22908.1	SAMN04515668_0387	SAMN04515668_1478	Methyl-accepting chemotaxis protein.	PAS domain S-box-containing protein.	0.999
SFP79979.1	SFQ51352.1	SAMN04515668_0387	SAMN04515668_2704	Methyl-accepting chemotaxis protein.	PAS domain S-box-containing protein.	0.999
SFP79979.1	SFQ51536.1	SAMN04515668_0387	SAMN04515668_2719	Methyl-accepting chemotaxis protein.	PAS domain S-box-containing protein.	0.999
SFP79979.1	SFQ52148.1	SAMN04515668_0387	SAMN04515668_2764	Methyl-accepting chemotaxis protein.	PAS domain S-box-containing protein.	0.999
SFP79979.1	SFQ67487.1	SAMN04515668_0387	SAMN04515668_3632	Methyl-accepting chemotaxis protein.	PAS domain S-box-containing protein.	0.999
SFP79979.1	SFQ76515.1	SAMN04515668_0387	SAMN04515668_4220	Methyl-accepting chemotaxis protein.	Signal transduction histidine kinase.	0.999
SFP79979.1	SFQ77087.1	SAMN04515668_0387	SAMN04515668_4275	Methyl-accepting chemotaxis protein.	Hpt domain-containing protein.	0.999
SFP79979.1	SFQ79352.1	SAMN04515668_0387	SAMN04515668_4431	Methyl-accepting chemotaxis protein.	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains.	0.971

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Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.938

expected number of edges:

30

PPI enrichment p-value:

0.0156

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006091

Generation of precursor metabolites and energy

6 of 172

1.43

1.65

2.47e-05

GO:0006096

Glycolytic process

3 of 20

2.06

1.58

0.00085

GO:0006213

Pyrimidine nucleoside metabolic process

2 of 4

2.59

1.52

0.0016

GO:1901135

Carbohydrate derivative metabolic process

8 of 410

1.18

1.36

6.98e-06

GO:0055086

Nucleobase-containing small molecule metabolic process

6 of 233

1.3

1.35

9.57e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

3 of 27

1.93

1.15

0.0058

GO:0016744

Transketolase or transaldolase activity

2 of 7

2.34

0.97

0.0164

GO:0016832

Aldehyde-lyase activity

2 of 13

2.07

0.78

0.0358

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 574

0.83

0.47

0.0384

GO:0005737

Cytoplasm

9 of 2295

0.48

0.31

0.0384

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21110849

(2010) Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations.

2 of 18

1.93

0.91

0.0183

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3856

Glycolysis, and Transketolase or transaldolase activity

5 of 15

2.41

4.01

1.24e-08

CL:3847

Mixed, incl. Glycolysis / Gluconeogenesis, and NADPH regeneration

7 of 85

1.8

3.18

8.47e-09

CL:3858

Glycolysis

3 of 10

2.36

2.14

8.85e-05

CL:3860

Glycolysis

2 of 5

2.49

1.23

0.0056

CL:1351

5-Nucleotidase/apyrase, and Pyrimidine nucleoside metabolic process

2 of 6

2.41

1.18

0.0068

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00030

Pentose phosphate pathway

5 of 82

1.67

2.13

6.41e-06

map00010

Glycolysis / Gluconeogenesis

4 of 105

1.47

1.33

0.00056

map01200

Carbon metabolism

5 of 240

1.21

1.09

0.00056

map01230

Biosynthesis of amino acids

4 of 257

1.08

0.76

0.0070

map01120

Microbial metabolism in diverse environments

6 of 829

0.75

0.53

0.0070

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

3 of 61

1.58

1.21

0.0021

MAP-168256

Immune System

3 of 72

1.51

1.17

0.0021

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0704

Schiff base

2 of 7

2.34

1.03

0.0126

KW-0324

Glycolysis

2 of 10

2.19

1.02

0.0126

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