STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERH14388.1Ribosomal RNA large subunit methyltransferase J; KEGG: ahe:Arch_0946 1.1e-92 hemolysin A; K06442 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase; Psort location: Cytoplasmic, score: 7.50. (277 aa)    
Predicted Functional Partners:
nadK
Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
  
 0.950
ERH14390.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
 
    0.864
ERH14391.1
Thiaminepyrophosphokinase, catalytic domain protein; KEGG: sit:TM1040_1966 0.00010 thiamine pyrophosphokinase; K00949 thiamine pyrophosphokinase; Psort location: Cytoplasmic, score: 7.50.
       0.842
ERH14386.1
Hypothetical protein; KEGG: ase:ACPL_6362 2.3e-28 Replicase polyprotein 1ab; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.838
ERH14387.1
HAD hydrolase, family IIA; KEGG: blw:W7Y_0734 6.5e-54 4-nitrophenylphosphatase; Psort location: Cytoplasmic, score: 7.50.
     
 0.832
ERH14392.1
Hypothetical protein; KEGG: ctu:CTU_13460 5.3e-05 tolA; cell envelope integrity inner membrane protein TolA K03646.
       0.824
ERH14393.1
Hypothetical protein; KEGG: gau:GAU_1280 0.0083 purN; phosphoribosylglycinamide formyltransferase K11175.
       0.746
ERH14385.1
Hypothetical protein; KEGG: azc:AZC_1265 0.0089 ribH; 6,7-dimethyl-8-ribityllumazine synthase; K00794 6,7-dimethyl-8-ribityllumazine synthase; Psort location: CytoplasmicMembrane, score: 9.55.
       0.557
ERH18995.1
Isochorismatase family protein; KEGG: mcu:HMPREF0573_10449 3.6e-76 pncA; putative nicotinamidase K08281; Psort location: Cytoplasmic, score: 9.97.
     
 0.556
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.534
Your Current Organism:
Actinobaculum sp. F0552
NCBI taxonomy Id: 1227261
Other names: A. sp. oral taxon 183 str. F0552, Actinobaculum sp. oral taxon 183 str. F0552
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.