D271_01954 protein (Lactobacillus saerimneri)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

D271_01954

COG2404 Predicted phosphohydrolase (DHH superfamily). (358 aa)

Predicted Functional Partners:

D271_02294

0.758

D271_02634

0.747

D271_05930

0.727

D271_02999

0.665

D271_00265

0.663

D271_01924

0.616

D271_03914

0.603

D271_01949

0.533

D271_06820

0.519

D271_00538

0.495

Your Current Organism:

Lactobacillus saerimneri

NCBI taxonomy Id: 1227363
Other names: L. saerimneri 30a, Lactobacillus saerimneri 30a

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
D271_00265	D271_01954	COG1309 Transcriptional regulator.	COG2404 Predicted phosphohydrolase (DHH superfamily).	0.663
D271_00265	D271_03914	COG1309 Transcriptional regulator.	Hypothetical protein.	0.413
D271_00538	D271_01954	N-acetylmuramoyl-L-alanine amidase; COG5263 FOG: Glucan-binding domain (YG repeat).	COG2404 Predicted phosphohydrolase (DHH superfamily).	0.495
D271_00538	D271_02294	N-acetylmuramoyl-L-alanine amidase; COG5263 FOG: Glucan-binding domain (YG repeat).	Hypothetical protein; COG5263 FOG: Glucan-binding domain (YG repeat).	0.542
D271_01924	D271_01954	Hypothetical protein; COG0550 Topoisomerase IA.	COG2404 Predicted phosphohydrolase (DHH superfamily).	0.616
D271_01924	D271_02294	Hypothetical protein; COG0550 Topoisomerase IA.	Hypothetical protein; COG5263 FOG: Glucan-binding domain (YG repeat).	0.503
D271_01924	D271_03914	Hypothetical protein; COG0550 Topoisomerase IA.	Hypothetical protein.	0.503
D271_01949	D271_01954	Mannose-6-phosphate isomerase, class I; COG1482 Phosphomannose isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family.	COG2404 Predicted phosphohydrolase (DHH superfamily).	0.533
D271_01954	D271_00265	COG2404 Predicted phosphohydrolase (DHH superfamily).	COG1309 Transcriptional regulator.	0.663
D271_01954	D271_00538	COG2404 Predicted phosphohydrolase (DHH superfamily).	N-acetylmuramoyl-L-alanine amidase; COG5263 FOG: Glucan-binding domain (YG repeat).	0.495
D271_01954	D271_01924	COG2404 Predicted phosphohydrolase (DHH superfamily).	Hypothetical protein; COG0550 Topoisomerase IA.	0.616
D271_01954	D271_01949	COG2404 Predicted phosphohydrolase (DHH superfamily).	Mannose-6-phosphate isomerase, class I; COG1482 Phosphomannose isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family.	0.533
D271_01954	D271_02294	COG2404 Predicted phosphohydrolase (DHH superfamily).	Hypothetical protein; COG5263 FOG: Glucan-binding domain (YG repeat).	0.758
D271_01954	D271_02634	COG2404 Predicted phosphohydrolase (DHH superfamily).	DNA-entry nuclease.	0.747
D271_01954	D271_02999	COG2404 Predicted phosphohydrolase (DHH superfamily).	COG4086 Predicted secreted protein.	0.665
D271_01954	D271_03914	COG2404 Predicted phosphohydrolase (DHH superfamily).	Hypothetical protein.	0.603
D271_01954	D271_05930	COG2404 Predicted phosphohydrolase (DHH superfamily).	Metallophosphoesterase; COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases.	0.727
D271_01954	D271_06820	COG2404 Predicted phosphohydrolase (DHH superfamily).	ssDNA-specific exonuclease RecJ; COG0608 Single-stranded DNA-specific exonuclease.	0.519
D271_02294	D271_00538	Hypothetical protein; COG5263 FOG: Glucan-binding domain (YG repeat).	N-acetylmuramoyl-L-alanine amidase; COG5263 FOG: Glucan-binding domain (YG repeat).	0.542
D271_02294	D271_01924	Hypothetical protein; COG5263 FOG: Glucan-binding domain (YG repeat).	Hypothetical protein; COG0550 Topoisomerase IA.	0.503

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.914

expected number of edges:

14

PPI enrichment p-value:

8.38e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007018

Microtubule-based movement

9 of 306

1.83

4.12

2.94e-12

GO:0098971

Anterograde dendritic transport of neurotransmitter receptor complex

3 of 6

3.06

2.67

1.41e-05

GO:0098840

Protein transport along microtubule

3 of 8

2.93

2.57

2.08e-05

GO:0048489

Synaptic vesicle transport

3 of 29

2.37

1.95

0.00021

GO:0008089

Anterograde axonal transport

3 of 33

2.32

1.89

0.00026

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008574

Plus-end-directed microtubule motor activity

5 of 18

2.8

4.96

4.96e-10

GO:0019894

Kinesin binding

4 of 41

2.35

2.94

1.96e-06

GO:0008017

Microtubule binding

5 of 282

1.61

1.82

3.65e-05

GO:0008092

Cytoskeletal protein binding

9 of 1141

1.26

1.74

5.74e-08

GO:0016887

ATP hydrolysis activity

4 of 338

1.43

1.07

0.0031

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005871

Kinesin complex

8 of 62

2.47

7.3

4.89e-16

GO:0005874

Microtubule

9 of 395

1.72

3.79

1.46e-12

GO:0035253

Ciliary rootlet

3 of 14

2.69

2.84

5.31e-06

GO:0032839

Dendrite cytoplasm

3 of 15

2.66

2.82

5.79e-06

GO:1904115

Axon cytoplasm

3 of 38

2.26

2.16

6.90e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4794

RHO GTPases activate KTN1

9 of 11

3.27

12.54

4.14e-24

CL:4797

RHO GTPases activate KTN1

5 of 5

3.36

6.55

1.15e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

5 of 588

1.29

1.17

0.00057

map05132

Salmonella infection

4 of 439

1.32

1.02

0.0028

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5625970

RHO GTPases activate KTN1

7 of 14

3.06

8.84

2.52e-17

MAP-983189

Kinesins

9 of 93

2.35

7.48

1.87e-17

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

9 of 156

2.12

6.18

5.42e-16

MAP-8856688

Golgi-to-ER retrograde transport

9 of 187

2.04

5.71

1.98e-15

MAP-983231

Factors involved in megakaryocyte development and platelet production

9 of 209

1.99

5.43

4.20e-15

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005871

Kinesin complex

7 of 43

2.57

6.69

3.98e-14

GOCC:0015630

Microtubule cytoskeleton

8 of 554

1.52

2.54

4.70e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0802

TPR repeat

5 of 107

2.03

3.06

2.55e-07

KW-0505

Motor protein

5 of 132

1.94

2.89

3.53e-07

KW-0493

Microtubule

4 of 92

2.0

2.45

7.56e-06

KW-0067

ATP-binding

5 of 1220

0.97

0.69

0.0069

KW-0175

Coiled coil

10 of 5391

0.63

0.54

0.00016

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13374

Tetratricopeptide repeat

3 of 7

2.99

2.61

1.76e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

5 of 55

2.32

3.8

2.37e-08

SM00028

Tetratricopeptide repeats

5 of 90

2.1

3.27

1.25e-07

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