node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C446_02537 | C446_12082 | C446_02537 | C446_12082 | COG0139 Phosphoribosyl-AMP cyclohydrolase. | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.983 |
C446_02537 | hisA | C446_02537 | C446_07297 | COG0139 Phosphoribosyl-AMP cyclohydrolase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.999 |
C446_02537 | hisB | C446_02537 | C446_02662 | COG0139 Phosphoribosyl-AMP cyclohydrolase. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.998 |
C446_02537 | hisE | C446_02537 | C446_14139 | COG0139 Phosphoribosyl-AMP cyclohydrolase. | COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.996 |
C446_02537 | hisF | C446_02537 | C446_16335 | COG0139 Phosphoribosyl-AMP cyclohydrolase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
C446_02537 | hisG | C446_02537 | C446_03169 | COG0139 Phosphoribosyl-AMP cyclohydrolase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.997 |
C446_02537 | hisH | C446_02537 | C446_11702 | COG0139 Phosphoribosyl-AMP cyclohydrolase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.996 |
C446_12082 | C446_02537 | C446_12082 | C446_02537 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG0139 Phosphoribosyl-AMP cyclohydrolase. | 0.983 |
C446_12082 | C446_12087 | C446_12082 | C446_12087 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Hypothetical protein; COG2038 NaMN:DMB phosphoribosyltransferase; Belongs to the UPF0284 family. | 0.971 |
C446_12082 | cobD | C446_12082 | C446_12102 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.987 |
C446_12082 | cobQ | C446_12082 | C446_09503 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.992 |
C446_12082 | hisA | C446_12082 | C446_07297 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.980 |
C446_12082 | hisB | C446_12082 | C446_02662 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.998 |
C446_12082 | hisE | C446_12082 | C446_14139 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.968 |
C446_12082 | hisF | C446_12082 | C446_16335 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.995 |
C446_12082 | hisG | C446_12082 | C446_03169 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.984 |
C446_12082 | hisH | C446_12082 | C446_11702 | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.995 |
C446_12087 | C446_12082 | C446_12087 | C446_12082 | Hypothetical protein; COG2038 NaMN:DMB phosphoribosyltransferase; Belongs to the UPF0284 family. | L-threonine-O-3-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.971 |
C446_12087 | cobD | C446_12087 | C446_12102 | Hypothetical protein; COG2038 NaMN:DMB phosphoribosyltransferase; Belongs to the UPF0284 family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.930 |
C446_12087 | cobQ | C446_12087 | C446_09503 | Hypothetical protein; COG2038 NaMN:DMB phosphoribosyltransferase; Belongs to the UPF0284 family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.792 |