STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 0.999
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.999
Hsw_2947
2-isopropylmalate synthase; COG0119; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.994
ilvD
Dihydroxyacid dehydratase; COG0129; Belongs to the IlvD/Edd family.
 
  
 0.973
Hsw_2944
Ketol-acid reductoisomerase; COG0059.
 
  
 0.956
Hsw_3223
Pyruvate dehydrogenase (cytochrome); COG0028; Belongs to the TPP enzyme family.
 
 
 0.898
Hsw_2943
Acetolactate synthase, small subunit; COG0440.
 
  
 0.880
Hsw_4120
Isocitrate dehydrogenase (NAD(+)); COG0473.
 
 0.828
Hsw_1770
Hypothetical protein; COG1052; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.824
Hsw_0742
Pyruvate kinase; COG0469; Belongs to the pyruvate kinase family.
    
 0.820
Your Current Organism:
Hymenobacter swuensis
NCBI taxonomy Id: 1227739
Other names: H. swuensis DY53, Hymenobacter sp. DY53, Hymenobacter swuensis DY53
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.