STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFT88921.1Dihydrofolate synthase; Identified by sequence similarity; putative; Belongs to the folylpolyglutamate synthase family. (436 aa)    
Predicted Functional Partners:
AFT86649.1
Dihydropteroate synthase; Identified by sequence similarity; putative.
 
 0.996
AFT86740.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.927
AFT88922.1
DedD protein; Identified by sequence similarity; putative.
 
  
 0.856
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.855
AFT88923.1
Hypothetical protein.
 
  
 0.786
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.761
AFT84581.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Identified by sequence similarity; putative.
 
  
 0.734
AFT86913.1
Riboflavin kinase; Identified by sequence similarity; putative; Belongs to the ribF family.
 
 
 
 0.733
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.711
folE
GTP cyclohydrolase I; Identified by sequence similarity; putative.
 
  
 0.690
Your Current Organism:
Paraburkholderia phenoliruptrix
NCBI taxonomy Id: 1229205
Other names: Burkholderia phenoliruptrix BR3459a, P. phenoliruptrix BR3459a, Paraburkholderia phenoliruptrix BR3459a
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