STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arcProteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. (585 aa)    
Predicted Functional Partners:
CCM64524.1
Proteasome subunit alpha (modular protein); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.999
prcB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.999
pup
Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family.
 
 
 
 0.998
CCM65586.1
Putative CysO-cysteine peptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 0.997
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
 
 
 0.994
glpK-2
Glycerol kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FGGY kinase family.
 
 
 0.994
CCM64963.1
Hypothetical protein; No homology to any previously reported sequences.
    
 0.992
CCM62529.1
Putative HtrA2 peptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.982
CCM62579.1
Hypothetical protein; No homology to any previously reported sequences.
    
 0.982
CCM64534.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
 0.971
Your Current Organism:
Microthrix parvicella
NCBI taxonomy Id: 1229780
Other names: C. Microthrix parvicella RN1, Candidatus Microthrix parvicella RN1, Candidatus Microthrix parvicella str. RN1, Candidatus Microthrix parvicella strain RN1
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