STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvCAcetohydroxy-acid isomeroreductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (346 aa)    
Predicted Functional Partners:
ilvD
Dihydroxy-acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
 
 
 0.997
ilvH
Acetolactate synthase III, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.997
ilvI
Acetolactate synthase III, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.992
CCM64005.1
Putative Acetolactate synthase, large subunit (IlvB-4); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the TPP enzyme family.
 
 
 0.981
leuC
3-isopropylmalate dehydratase (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.975
CCM65934.1
Pyruvate oxidase; Belongs to the TPP enzyme family.
 
 
 0.970
ilvX
Putative acetolactate synthase large subunit IlvX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 
 0.963
yeaU
Putative tartrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.937
leuD
3-isopropylmalate dehydratase (small subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.932
CCM63920.1
Hypothetical protein; No homology to any previously reported sequences.
  
 
 0.920
Your Current Organism:
Microthrix parvicella
NCBI taxonomy Id: 1229780
Other names: C. Microthrix parvicella RN1, Candidatus Microthrix parvicella RN1, Candidatus Microthrix parvicella str. RN1, Candidatus Microthrix parvicella strain RN1
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