STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (471 aa)    
Predicted Functional Partners:
C476_04390
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
 0.985
C476_04395
COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit.
 
 0.973
C476_04440
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
 0.973
C476_12406
COG0039 Malate/lactate dehydrogenases; Belongs to the LDH/MDH superfamily.
  
 0.968
C476_04405
COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit.
   
 
 0.957
sucD
succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.948
C476_12031
Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes.
   
 
 0.922
C476_07027
2-methylcitrate synthase/citrate synthase II; COG0372 Citrate synthase.
   
 0.919
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.912
C476_10991
Malate dehydrogenase, phosphate acetyltransferase; COG0281 Malic enzyme.
  
 
 0.908
Your Current Organism:
Haloterrigena limicola
NCBI taxonomy Id: 1230457
Other names: H. limicola JCM 13563, Haloterrigena limicola AX-7, Haloterrigena limicola JCM 13563, Haloterrigena sp. AX-7, Haloterrigena sp. strain AX-7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.