STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
LAMI_0F04522GFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (490 aa)    
Predicted Functional Partners:
LAMI_0F02630G
Folic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family. In the central section; belongs to the HPPK family.
 
 
 0.913
LAMI_0H05754G
LAMI_0H05754g1_1; Belongs to the dihydrofolate reductase family.
     
 0.890
LAMI_0H10044G
LAMI_0H10044g1_1.
     
 0.866
LAMI_0G05094G
Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family.
  
  
0.815
LAMI_0A08592G
LAMI_0A08592g1_1.
     
 0.798
LAMI_0D06700G
Tryptophan synthase.
     
 0.798
LAMI_0H03554G
LAMI_0H03554g1_1.
     
 0.787
LAMI_0H09934G
LAMI_0H09934g1_1.
    
 0.724
LAMI_0C03268G
Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
 0.712
LAMI_0E10726G
D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.687
Your Current Organism:
Lachancea mirantina
NCBI taxonomy Id: 1230905
Other names: CBS 11717, L. mirantina, Lachancea mirantina Pereira, Costa, Brasileiro, Rosa & Morais, 2011, Lachancea sp. CBS 11717, Lachancea sp. PJ-2012b, URM 5925
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