STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAHE_0017Putative uncharacterized protein; Homologs of previously reported genes of unknown function; Belongs to the DNA mismatch repair MutS family. (704 aa)    
Predicted Functional Partners:
mutL
DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 0.986
mutS
DNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
  
  
 
0.929
CAHE_0267
Putative uncharacterized protein; Homologs of previously reported genes of unknown function; Belongs to the DNA mismatch repair MutS family.
  
  
0.916
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.898
CAHE_0487
DNA polymerase type I.
   
 0.881
topA
DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.714
CAHE_0633
Membrane protein of unknown function; No homology to any previously reported sequences.
  
    0.648
CAHE_0431
Membrane protein of unknown function; No homology to any previously reported sequences.
  
    0.641
recQ
ATP-dependent DNA helicase recQ; Homologs of previously reported genes of unknown function.
  
 0.639
CAHE_0118
Afp14-like protein; No homology to any previously reported sequences; Product derived from manual annotation.
 
 
 0.618
Your Current Organism:
Cardinium endosymbiont cEper1
NCBI taxonomy Id: 1231626
Other names: C. endosymbiont cEper1 of Encarsia pergandiella, Cardinium endosymbiont cEper1 of Encarsia pergandiella, Cardinium hertigii cEper1
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