STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACO03573.1Putative DNA double-strand break repair protein Rad50; Identified by match to protein family HMM PF00005; match to protein family HMM PF02463. (893 aa)    
Predicted Functional Partners:
ACO03354.1
Metallophosphoesterase; Identified by match to protein family HMM PF00149.
 
 0.999
ACO03074.1
DNA polymerase I; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.
  
 0.950
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.910
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.904
lig
DNA ligase (Polydeoxyribonucleotide synthase [ATP])(Lig(Tk)); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 0.891
ACO03044.1
DNA polymerase I; Identified by match to protein family HMM PF00476; match to protein family HMM PF01612.
   
 
 0.855
ACO03433.1
DNA polymerase III, delta prime subunit.
    
 0.803
ACO03621.1
Mov34/MPN/PAD-1 family protein.
    
  0.798
ACO04526.1
Conserved hypothetical protein; Identified by match to protein family HMM PF01910; match to protein family HMM TIGR00106.
       0.798
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
  0.774
Your Current Organism:
Persephonella marina
NCBI taxonomy Id: 123214
Other names: P. marina EX-H1, Persephonella marina EX-H1, Persephonella marina str. EX-H1, Persephonella marina strain EX-H1, bacterium EX-H1
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