node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GAF09155.1 | hisA | JCM16418_3275 | JCM16418_3271 | Ribose-phosphate pyrophosphokinase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.653 |
GAF09155.1 | hisB | JCM16418_3275 | JCM16418_3269 | Ribose-phosphate pyrophosphokinase. | Imidazoleglycerol-phosphate dehydratase. | 0.563 |
GAF09155.1 | hisD | JCM16418_3275 | JCM16418_3268 | Ribose-phosphate pyrophosphokinase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.558 |
GAF09155.1 | hisF | JCM16418_3275 | JCM16418_3272 | Ribose-phosphate pyrophosphokinase. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.658 |
GAF09155.1 | hisG | JCM16418_3275 | JCM16418_3267 | Ribose-phosphate pyrophosphokinase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.911 |
GAF09155.1 | hisH | JCM16418_3275 | JCM16418_3270 | Ribose-phosphate pyrophosphokinase. | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.491 |
GAF09155.1 | hisI | JCM16418_3275 | JCM16418_3273 | Ribose-phosphate pyrophosphokinase. | phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.761 |
GAF09155.1 | hisS | JCM16418_3275 | JCM16418_754 | Ribose-phosphate pyrophosphokinase. | histidyl-tRNA synthetase. | 0.556 |
GAF09155.1 | hisZ | JCM16418_3275 | JCM16418_3266 | Ribose-phosphate pyrophosphokinase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.891 |
hisA | GAF09155.1 | JCM16418_3271 | JCM16418_3275 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Ribose-phosphate pyrophosphokinase. | 0.653 |
hisA | hisB | JCM16418_3271 | JCM16418_3269 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | JCM16418_3271 | JCM16418_3190 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Biosynthetic aromatic amino acid aminotransferase beta; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.876 |
hisA | hisD | JCM16418_3271 | JCM16418_3268 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisF | JCM16418_3271 | JCM16418_3272 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | JCM16418_3271 | JCM16418_3267 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.998 |
hisA | hisH | JCM16418_3271 | JCM16418_3270 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | JCM16418_3271 | JCM16418_3273 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | JCM16418_3271 | JCM16418_3266 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.978 |
hisB | GAF09155.1 | JCM16418_3269 | JCM16418_3275 | Imidazoleglycerol-phosphate dehydratase. | Ribose-phosphate pyrophosphokinase. | 0.563 |
hisB | hisA | JCM16418_3269 | JCM16418_3271 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.998 |