STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaABGMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; Catalyzes the synthesis of GMP from XMP. (305 aa)    
Predicted Functional Partners:
guaB
Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 0.997
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 0.994
guaAA
GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit; Catalyzes the synthesis of GMP from XMP.
  
 0.993
ERG99319.1
Adenine/guanine phosphoribosyltransferase.
  
 0.965
ERG98743.1
GMP synthase - glutamine amidotransferase domain protein.
 
  
 0.907
ERG97884.1
Pseudouridine synthase.
 
  
 0.891
ERG99723.1
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Belongs to the HAM1 NTPase family.
 
 
 0.868
ERG99337.1
NADH:ubiquinone oxidoreductase 49 kD subunit 7.
   
  
 0.867
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
  
 
 0.867
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
  
  
 0.850
Your Current Organism:
Haloquadratum sp. J07HQX50
NCBI taxonomy Id: 1238426
Other names: H. sp. J07HQX50
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