| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EME68125.1 | EME69589.1 | H261_20018 | H261_12664 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COG0031 Cysteine synthase. | 0.944 |
| EME68125.1 | EME70123.1 | H261_20018 | H261_09969 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | 0.990 |
| EME68125.1 | EME71699.1 | H261_20018 | H261_02166 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COG0031 Cysteine synthase. | 0.944 |
| EME68125.1 | EME71795.1 | H261_20018 | H261_01062 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COG2873 O-acetylhomoserine sulfhydrylase. | 0.988 |
| EME68125.1 | EME71902.1 | H261_20018 | H261_01607 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.568 |
| EME68125.1 | ahcY | H261_20018 | H261_09497 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.988 |
| EME68125.1 | metXA | H261_20018 | H261_17288 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.938 |
| EME68125.1 | metZ | H261_20018 | H261_08758 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.990 |
| EME68544.1 | EME68874.1 | H261_17873 | H261_16191 | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | Sulfide dehydrogenase (flavocytochrome), flavoprotein subunit; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | 0.939 |
| EME68544.1 | EME69589.1 | H261_17873 | H261_12664 | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0031 Cysteine synthase. | 0.941 |
| EME68544.1 | EME70123.1 | H261_17873 | H261_09969 | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | 0.423 |
| EME68544.1 | EME71699.1 | H261_17873 | H261_02166 | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0031 Cysteine synthase. | 0.941 |
| EME68544.1 | EME71795.1 | H261_17873 | H261_01062 | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG2873 O-acetylhomoserine sulfhydrylase. | 0.438 |
| EME68544.1 | EME71902.1 | H261_17873 | H261_01607 | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.951 |
| EME68544.1 | metZ | H261_17873 | H261_08758 | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.941 |
| EME68874.1 | EME68544.1 | H261_16191 | H261_17873 | Sulfide dehydrogenase (flavocytochrome), flavoprotein subunit; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | 0.939 |
| EME68874.1 | EME69589.1 | H261_16191 | H261_12664 | Sulfide dehydrogenase (flavocytochrome), flavoprotein subunit; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0031 Cysteine synthase. | 0.940 |
| EME68874.1 | EME70123.1 | H261_16191 | H261_09969 | Sulfide dehydrogenase (flavocytochrome), flavoprotein subunit; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | 0.423 |
| EME68874.1 | EME71699.1 | H261_16191 | H261_02166 | Sulfide dehydrogenase (flavocytochrome), flavoprotein subunit; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG0031 Cysteine synthase. | 0.940 |
| EME68874.1 | EME71795.1 | H261_16191 | H261_01062 | Sulfide dehydrogenase (flavocytochrome), flavoprotein subunit; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. | COG2873 O-acetylhomoserine sulfhydrylase. | 0.438 |