| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EME68122.1 | EME68123.1 | H261_20003 | H261_20008 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.875 |
| EME68122.1 | EME68124.1 | H261_20003 | H261_20013 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | ATP-dependent helicase HrpA; COG2852 Uncharacterized protein conserved in bacteria. | 0.595 |
| EME68122.1 | EME68125.1 | H261_20003 | H261_20018 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.850 |
| EME68122.1 | EME69112.1 | H261_20003 | H261_14945 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | COG0463 Glycosyltransferases involved in cell wall biogenesis. | 0.643 |
| EME68122.1 | EME69375.1 | H261_20003 | H261_13828 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | Phenolpthiocerol synthesis polyketide synthase ppsA; COG3321 Polyketide synthase modules and related proteins. | 0.874 |
| EME68122.1 | EME70123.1 | H261_20003 | H261_09969 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | 0.595 |
| EME68122.1 | bioB | H261_20003 | H261_11119 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.745 |
| EME68122.1 | coq7 | H261_20003 | H261_16815 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | Ubiquinone biosynthesis protein COQ7; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. | 0.673 |
| EME68122.1 | metK | H261_20003 | H261_14380 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.619 |
| EME68122.1 | metZ | H261_20003 | H261_08758 | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.595 |
| EME68123.1 | EME68122.1 | H261_20008 | H261_20003 | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | 0.875 |
| EME68123.1 | EME68124.1 | H261_20008 | H261_20013 | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | ATP-dependent helicase HrpA; COG2852 Uncharacterized protein conserved in bacteria. | 0.810 |
| EME68123.1 | EME68125.1 | H261_20008 | H261_20018 | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
| EME68123.1 | EME70123.1 | H261_20008 | H261_09969 | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | 0.868 |
| EME68123.1 | metK | H261_20008 | H261_14380 | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.886 |
| EME68123.1 | metZ | H261_20008 | H261_08758 | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.868 |
| EME68124.1 | EME68122.1 | H261_20013 | H261_20003 | ATP-dependent helicase HrpA; COG2852 Uncharacterized protein conserved in bacteria. | SAM-dependent methyltransferase; COG0640 Predicted transcriptional regulators. | 0.595 |
| EME68124.1 | EME68123.1 | H261_20013 | H261_20008 | ATP-dependent helicase HrpA; COG2852 Uncharacterized protein conserved in bacteria. | COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.810 |
| EME68124.1 | EME68125.1 | H261_20013 | H261_20018 | ATP-dependent helicase HrpA; COG2852 Uncharacterized protein conserved in bacteria. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.896 |
| EME68124.1 | EME70123.1 | H261_20013 | H261_09969 | ATP-dependent helicase HrpA; COG2852 Uncharacterized protein conserved in bacteria. | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | 0.416 |