STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APE77390.1Acetolactate synthase isozyme 1 small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (81 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
 
 0.999
ilvB
Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.996
budB
Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.
  
 0.985
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.984
pox5
Pyruvate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.
  
 0.971
leuB_2
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.963
leuA
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.948
aldC_1
Alpha-acetolactate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-acetolactate decarboxylase family.
     
 0.910
aldC_2
Manganese ABC transporter substrate-binding protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-acetolactate decarboxylase family.
     
 0.910
APE75905.1
L-lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily.
   
 0.848
Your Current Organism:
Leuconostoc mesenteroides
NCBI taxonomy Id: 1245
Other names: ATCC 8293, Ascococcus mesenteroides, Betacoccus arabinosaceus, CCUG 30066, CIP 102305, DSM 20343, HAMBI 2347, JCM 6124, L. mesenteroides, LMG 6893, LMG:6893, Leuconostoc sp. 13HN, NBRC 100496, NCDO 523, NCTC 12954, NRRL B-3470, strain 12954
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