Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tsaDtRNA N6-adenosine(37)-threonylcarbamoyltransferase complex transferase subunit TsaD; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (336 aa)    
Predicted Functional Partners:
tsaB
tRNA N6-adenosine(37)-N6-threonylcarbamoyltransferase complex dimerization subunit TsaB; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.984
tsaE
tRNA (N6-adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase TsaE; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.901
ANY11826.1
threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
  
 0.793
rimI
Ribosomal-protein-alanine N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.780
rimI-2
Ribosomal-protein-alanine N-acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.
  
  
 0.780
pheS
phenylalanine--tRNA ligase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
 
   
 0.731
pheT
phenylalanine--tRNA ligase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
 
   
 0.699
rsmA
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.674
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.614
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.561
Your Current Organism:
Leuconostoc lactis
NCBI taxonomy Id: 1246
Other names: ATCC 19256, CCUG 30064, CCUG 38887 [[Leuconostoc argentinum]], CIP 102422, CIP 103889 [[Leuconostoc argentinum]], DSM 20202, DSM 8581 [[Leuconostoc argentinum]], HAMBI 2346, JCM 11052 [[Leuconostoc argentinum]], JCM 6123, KCTC 3528, KCTC 3773 [[Leuconostoc argentinum]], L. lactis, LMG 8894, LMG:8894, Leuconostoc argentinum, Leuconostoc sp. LMG 22650, Leuconostoc sp. R-21065, NCFB 533, NCIMB 13091, NRRL B-3468, strain Gibson L5, strain L5, strain LL76 [[Leuconostoc argentinum]]
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