STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (382 aa)    
Predicted Functional Partners:
PSACC_02100
Mitochondrial substrate/solute carrier domain-containing protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.
 
      0.803
PSACC_01450
SAM-dependent MTase TRM10-type domain-containing protein.
   
  
 0.682
PSACC_03310
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
   
  
 0.657
PSACC_03444
Uncharacterized protein.
   
  
 0.644
PSACC_02753
Uncharacterized protein.
   
  
 0.632
PSACC_00063
tRNA dimethylallyltransferase.
   
  
 0.626
PSACC_02016
Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.
   
  
 0.621
PSACC_01687
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
   
  
 0.619
PSACC_02624
Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.
 
 
    0.602
PSACC_00488
tRNA pseudouridine synthase.
   
  
 0.586
Your Current Organism:
Paramicrosporidium saccamoebae
NCBI taxonomy Id: 1246581
Other names: KSL3, P. saccamoebae, Paramicrosporidium saccamoebae Corsaro et al., 2014, fungal sp. KSL3
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