PSACC_03255 protein (Paramicrosporidium saccamoebae)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PSACC_03255

Amino acid permease. (630 aa)

Predicted Functional Partners:

PSACC_01146

0.689

PSACC_03118

0.653

PSACC_01141

0.647

PSACC_01945

0.627

PSACC_01336

0.625

PSACC_00865

0.625

PSACC_00558

0.625

PSACC_01946

0.613

PSACC_00503

0.535

PSACC_03329

0.524

Your Current Organism:

Paramicrosporidium saccamoebae

NCBI taxonomy Id: 1246581
Other names: KSL3, P. saccamoebae, Paramicrosporidium saccamoebae Corsaro et al., 2014, fungal sp. KSL3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSACC_00503	PSACC_01146	A0A2H9TPK0	A0A2H9TMQ1	WD_REPEATS_REGION domain-containing protein.	Cfr family radical SAM enzyme.	0.948
PSACC_00503	PSACC_03118	A0A2H9TPK0	A0A2H9THA1	WD_REPEATS_REGION domain-containing protein.	Fip1 domain-containing protein.	0.775
PSACC_00503	PSACC_03255	A0A2H9TPK0	A0A2H9TH26	WD_REPEATS_REGION domain-containing protein.	Amino acid permease.	0.535
PSACC_00503	PSACC_03329	A0A2H9TPK0	A0A2H9TGG4	WD_REPEATS_REGION domain-containing protein.	Histone H3; Belongs to the histone H3 family.	0.806
PSACC_00558	PSACC_01141	A0A2H9TPC0	A0A2H9TMS1	Fungal chitin synthase domain-containing protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.781
PSACC_00558	PSACC_01945	A0A2H9TPC0	A0A2H9TKG5	Fungal chitin synthase domain-containing protein.	Putative HD-1 (Homeodomain).	0.624
PSACC_00558	PSACC_01946	A0A2H9TPC0	A0A2H9TKE1	Fungal chitin synthase domain-containing protein.	Putative HD-2 (Homeodomain).	0.613
PSACC_00558	PSACC_03255	A0A2H9TPC0	A0A2H9TH26	Fungal chitin synthase domain-containing protein.	Amino acid permease.	0.625
PSACC_00865	PSACC_01141	A0A2H9TNM4	A0A2H9TMS1	Fungal chitin synthase domain-containing protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.781
PSACC_00865	PSACC_01945	A0A2H9TNM4	A0A2H9TKG5	Fungal chitin synthase domain-containing protein.	Putative HD-1 (Homeodomain).	0.624
PSACC_00865	PSACC_01946	A0A2H9TNM4	A0A2H9TKE1	Fungal chitin synthase domain-containing protein.	Putative HD-2 (Homeodomain).	0.613
PSACC_00865	PSACC_03255	A0A2H9TNM4	A0A2H9TH26	Fungal chitin synthase domain-containing protein.	Amino acid permease.	0.625
PSACC_01141	PSACC_00558	A0A2H9TMS1	A0A2H9TPC0	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Fungal chitin synthase domain-containing protein.	0.781
PSACC_01141	PSACC_00865	A0A2H9TMS1	A0A2H9TNM4	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Fungal chitin synthase domain-containing protein.	0.781
PSACC_01141	PSACC_01336	A0A2H9TMS1	A0A2H9TM59	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Fungal chitin synthase domain-containing protein.	0.781
PSACC_01141	PSACC_01945	A0A2H9TMS1	A0A2H9TKG5	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Putative HD-1 (Homeodomain).	0.613
PSACC_01141	PSACC_01946	A0A2H9TMS1	A0A2H9TKE1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Putative HD-2 (Homeodomain).	0.613
PSACC_01141	PSACC_03255	A0A2H9TMS1	A0A2H9TH26	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Amino acid permease.	0.647
PSACC_01146	PSACC_00503	A0A2H9TMQ1	A0A2H9TPK0	Cfr family radical SAM enzyme.	WD_REPEATS_REGION domain-containing protein.	0.948
PSACC_01146	PSACC_01945	A0A2H9TMQ1	A0A2H9TKG5	Cfr family radical SAM enzyme.	Putative HD-1 (Homeodomain).	0.470

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.618

expected number of edges:

14

PPI enrichment p-value:

5.26e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017183

Peptidyl-diphthamide biosynthetic process from peptidyl-histidine

5 of 8

2.68

4.35

5.72e-09

GO:0006417

Regulation of translation

7 of 140

1.58

2.47

7.55e-08

GO:0042256

Mature ribosome assembly

2 of 6

2.41

1.19

0.0064

GO:0002926

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation

2 of 6

2.41

1.19

0.0064

GO:0044249

Cellular biosynthetic process

8 of 1176

0.72

0.54

0.0035

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

6 of 93

1.69

2.35

1.42e-06

GO:0005525

GTP binding

6 of 120

1.58

2.09

3.09e-06

GO:0090560

2-(3-amino-3-carboxypropyl)histidine synthase activity

2 of 2

2.88

1.59

0.0013

GO:0043022

Ribosome binding

3 of 24

1.98

1.57

0.00076

GO:0034986

Iron chaperone activity

2 of 4

2.58

1.39

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5260

Synthesis of diphthamide-EEF2, and Ribosome disassembly

6 of 7

2.82

6.14

2.32e-12

CL:5230

tRNA wobble uridine modification, and Synthesis of diphthamide-EEF2

7 of 25

2.33

5.51

2.32e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5358493

Synthesis of diphthamide-EEF2

6 of 8

2.76

6.07

2.54e-12

MAP-163841

Gamma carboxylation, hypusine formation and arylsulfatase activation

6 of 16

2.46

5.23

3.15e-11

MAP-392499

Metabolism of proteins

8 of 806

0.88

0.78

0.00028

MAP-597592

Post-translational protein modification

6 of 520

0.95

0.7

0.0046

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070652

HAUS complex

2 of 5

2.49

0.82

0.0317

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0251

Elongation factor

4 of 15

2.31

2.99

1.40e-06

KW-0949

S-adenosyl-L-methionine

3 of 43

1.73

1.3

0.0019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00009

Elongation factor Tu GTP binding domain

6 of 12

2.58

5.53

1.51e-11

PF03144

Elongation factor Tu domain 2

3 of 9

2.41

2.02

0.00016

PF01866

Putative diphthamide synthesis protein

2 of 2

2.88

1.42

0.0027

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042265

Diphthamide synthesis DPH1/DPH2, domain 3

2 of 2

2.88

1.22

0.0061

IPR042263

Diphthamide synthesis DPH1/DPH2, domain 1

2 of 2

2.88

1.22

0.0061

IPR016435

Diphthamide synthesis DPH1/DPH2

2 of 2

2.88

1.22

0.0061

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00838

Elongation factor G C-terminus

5 of 5

2.88

5.35

9.91e-11

SM00889

Elongation factor G, domain IV

3 of 3

2.88

2.89

4.99e-06

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