PSACC_02623 protein (Paramicrosporidium saccamoebae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

PSACC_02623

Uncharacterized protein. (645 aa)

Predicted Functional Partners:

PSACC_01811

0.609

PSACC_02639

0.603

PSACC_01635

0.515

PSACC_01723

0.473

PSACC_02253

0.471

PSACC_00468

0.471

Your Current Organism:

Paramicrosporidium saccamoebae

NCBI taxonomy Id: 1246581
Other names: KSL3, P. saccamoebae, Paramicrosporidium saccamoebae Corsaro et al., 2014, fungal sp. KSL3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSACC_00468	PSACC_01635	A0A2H9TPN6	A0A2H9TLE5	Uncharacterized protein.	ARF/SAR superfamily.	0.453
PSACC_00468	PSACC_01811	A0A2H9TPN6	A0A2H9TKW9	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.731
PSACC_00468	PSACC_02623	A0A2H9TPN6	A0A2H9TIW7	Uncharacterized protein.	Uncharacterized protein.	0.471
PSACC_01635	PSACC_00468	A0A2H9TLE5	A0A2H9TPN6	ARF/SAR superfamily.	Uncharacterized protein.	0.453
PSACC_01635	PSACC_01723	A0A2H9TLE5	A0A2H9TL26	ARF/SAR superfamily.	Uncharacterized protein.	0.567
PSACC_01635	PSACC_01811	A0A2H9TLE5	A0A2H9TKW9	ARF/SAR superfamily.	Guanylate kinase-like domain-containing protein.	0.635
PSACC_01635	PSACC_02253	A0A2H9TLE5	A0A2H9TJL7	ARF/SAR superfamily.	Uncharacterized protein.	0.453
PSACC_01635	PSACC_02623	A0A2H9TLE5	A0A2H9TIW7	ARF/SAR superfamily.	Uncharacterized protein.	0.515
PSACC_01635	PSACC_02639	A0A2H9TLE5	A0A2H9TIE1	ARF/SAR superfamily.	NADH:ubiquinone oxidoreductase 18.4kD subunit.	0.571
PSACC_01723	PSACC_01635	A0A2H9TL26	A0A2H9TLE5	Uncharacterized protein.	ARF/SAR superfamily.	0.567
PSACC_01723	PSACC_01811	A0A2H9TL26	A0A2H9TKW9	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.713
PSACC_01723	PSACC_02623	A0A2H9TL26	A0A2H9TIW7	Uncharacterized protein.	Uncharacterized protein.	0.473
PSACC_01811	PSACC_00468	A0A2H9TKW9	A0A2H9TPN6	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.731
PSACC_01811	PSACC_01635	A0A2H9TKW9	A0A2H9TLE5	Guanylate kinase-like domain-containing protein.	ARF/SAR superfamily.	0.635
PSACC_01811	PSACC_01723	A0A2H9TKW9	A0A2H9TL26	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.713
PSACC_01811	PSACC_02253	A0A2H9TKW9	A0A2H9TJL7	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.731
PSACC_01811	PSACC_02623	A0A2H9TKW9	A0A2H9TIW7	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.609
PSACC_02253	PSACC_01635	A0A2H9TJL7	A0A2H9TLE5	Uncharacterized protein.	ARF/SAR superfamily.	0.453
PSACC_02253	PSACC_01811	A0A2H9TJL7	A0A2H9TKW9	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.731
PSACC_02253	PSACC_02623	A0A2H9TJL7	A0A2H9TIW7	Uncharacterized protein.	Uncharacterized protein.	0.471

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.847

expected number of edges:

17

PPI enrichment p-value:

0.11

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

3 of 16

1.74

0.95

0.0128

GO:0008610

Lipid biosynthetic process

4 of 65

1.26

0.78

0.0135

GO:0006091

Generation of precursor metabolites and energy

5 of 96

1.19

0.75

0.0128

GO:0044255

Cellular lipid metabolic process

4 of 94

1.1

0.56

0.0446

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050136

NADH dehydrogenase (quinone) activity

5 of 17

1.94

2.57

2.62e-06

GO:0048038

Quinone binding

5 of 19

1.89

2.52

2.62e-06

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 12

1.99

2.36

1.21e-05

GO:0051539

4 iron, 4 sulfur cluster binding

4 of 31

1.58

1.54

0.00024

GO:0016491

Oxidoreductase activity

7 of 304

0.83

0.68

0.00098

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1619

Quinone binding

5 of 15

1.99

2.71

1.65e-06

CL:1762

Isoprenoid metabolic process, and Menaquinone metabolic process

4 of 18

1.82

1.95

5.96e-05

CL:1621

Quinone, and Electron transport coupled proton transport

3 of 9

1.99

1.68

0.00044

CL:1782

Carotenoid biosynthesis, and Cytochrome P450

2 of 6

1.99

0.95

0.0158

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

5 of 56

1.42

1.49

0.00010

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030964

NADH dehydrogenase complex

3 of 11

1.91

1.27

0.0031

GOCC:0045272

Plasma membrane respiratory chain complex I

2 of 5

2.07

0.8

0.0325

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0874

Quinone

5 of 11

2.13

3.41

6.63e-08

KW-0830

Ubiquinone

6 of 22

1.91

3.26

2.09e-08

KW-1278

Translocase

4 of 14

1.93

2.28

1.43e-05

KW-0520

NAD

5 of 45

1.52

1.81

1.53e-05

KW-0004

4Fe-4S

4 of 34

1.54

1.55

0.00017

(more ...)

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