PSACC_00976 protein (Paramicrosporidium saccamoebae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PSACC_00976

Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (381 aa)

Predicted Functional Partners:

PSACC_02699

0.999

PSACC_02055

0.999

PSACC_02018

0.999

PSACC_00341

0.999

PSACC_03740

0.997

PSACC_02922

0.997

PSACC_01468

0.995

PSACC_01553

0.992

PSACC_00035

0.992

PSACC_03400

0.988

Your Current Organism:

Paramicrosporidium saccamoebae

NCBI taxonomy Id: 1246581
Other names: KSL3, P. saccamoebae, Paramicrosporidium saccamoebae Corsaro et al., 2014, fungal sp. KSL3

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSACC_00035	PSACC_00341	A0A2H9TR04	A0A2H9TQ11	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	TFIIB-type domain-containing protein.	0.998
PSACC_00035	PSACC_00976	A0A2H9TR04	A0A2H9TNA9	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	0.992
PSACC_00035	PSACC_01468	A0A2H9TR04	A0A2H9TLV7	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	ATP-dependent helicase domain-containing protein.	0.971
PSACC_00035	PSACC_01553	A0A2H9TR04	A0A2H9TLM0	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.972
PSACC_00035	PSACC_02018	A0A2H9TR04	A0A2H9TKC5	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Putative CDK-activating kinase assembly factor MAT1.	0.976
PSACC_00035	PSACC_02055	A0A2H9TR04	A0A2H9TK40	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Cyclin N-terminal domain-containing protein.	0.968
PSACC_00035	PSACC_02699	A0A2H9TR04	A0A2H9TIF1	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Tata-Box binding protein YtbP.	0.993
PSACC_00035	PSACC_02922	A0A2H9TR04	A0A2H9THR0	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.914
PSACC_00035	PSACC_03400	A0A2H9TR04	A0A2H9TGA1	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Putative DNA excision repair protein ERCC-3.	0.988
PSACC_00035	PSACC_03740	A0A2H9TR04	A0A2H9TF91	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Transcription initiation factor IIE subunit alpha.	0.997
PSACC_00341	PSACC_00035	A0A2H9TQ11	A0A2H9TR04	TFIIB-type domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.998
PSACC_00341	PSACC_00976	A0A2H9TQ11	A0A2H9TNA9	TFIIB-type domain-containing protein.	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	0.999
PSACC_00341	PSACC_01468	A0A2H9TQ11	A0A2H9TLV7	TFIIB-type domain-containing protein.	ATP-dependent helicase domain-containing protein.	0.985
PSACC_00341	PSACC_01553	A0A2H9TQ11	A0A2H9TLM0	TFIIB-type domain-containing protein.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.988
PSACC_00341	PSACC_02018	A0A2H9TQ11	A0A2H9TKC5	TFIIB-type domain-containing protein.	Putative CDK-activating kinase assembly factor MAT1.	0.983
PSACC_00341	PSACC_02055	A0A2H9TQ11	A0A2H9TK40	TFIIB-type domain-containing protein.	Cyclin N-terminal domain-containing protein.	0.959
PSACC_00341	PSACC_02699	A0A2H9TQ11	A0A2H9TIF1	TFIIB-type domain-containing protein.	Tata-Box binding protein YtbP.	0.999
PSACC_00341	PSACC_02922	A0A2H9TQ11	A0A2H9THR0	TFIIB-type domain-containing protein.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.991
PSACC_00341	PSACC_03400	A0A2H9TQ11	A0A2H9TGA1	TFIIB-type domain-containing protein.	Putative DNA excision repair protein ERCC-3.	0.993
PSACC_00341	PSACC_03740	A0A2H9TQ11	A0A2H9TF91	TFIIB-type domain-containing protein.	Transcription initiation factor IIE subunit alpha.	0.995

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

35

PPI enrichment p-value:

0.000516

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

7 of 79

1.38

1.73

4.26e-06

GO:0018106

Peptidyl-histidine phosphorylation

4 of 36

1.48

1.28

0.00086

GO:0016310

Phosphorylation

5 of 91

1.17

1.01

0.0010

GO:0050896

Response to stimulus

8 of 262

0.92

0.87

7.87e-05

GO:0050794

Regulation of cellular process

9 of 337

0.86

0.83

2.78e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

6 of 40

1.61

2.16

2.46e-06

GO:0016301

Kinase activity

7 of 93

1.31

1.65

2.46e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

9 of 521

0.67

0.55

0.00074

GO:0016021

Integral component of membrane

8 of 568

0.58

0.42

0.0067

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3372

Mixed, incl. MacB, ATP-binding domain, and DegT/DnrJ/EryC1/StrS aminotransferase family

4 of 5

2.34

2.96

1.68e-06

CL:3180

GGDEF domain, and His Kinase A (phosphoacceptor) domain

7 of 44

1.63

2.6

5.83e-08

CL:3234

Two-component regulatory system, and PAS domain

4 of 14

1.89

2.14

2.69e-05

CL:3237

Two-component regulatory system, and cheY-homologous receiver domain

3 of 6

2.13

1.91

0.00019

CL:3191

HPT domain superfamily, and GAF domain

3 of 7

2.06

1.82

0.00025

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

5 of 49

1.44

1.56

6.63e-05

KW-0418

Kinase

6 of 73

1.35

1.54

2.29e-05

KW-0902

Two-component regulatory system

3 of 20

1.61

1.12

0.0041

KW-0067

ATP-binding

6 of 237

0.84

0.62

0.0043

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 19

2.0

3.94

6.28e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 22

1.94

3.78

7.42e-10

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 24

1.9

3.68

8.32e-10

IPR005467

Histidine kinase domain

7 of 25

1.88

3.64

8.32e-10

IPR003594

Histidine kinase/HSP90-like ATPase

7 of 29

1.82

3.41

1.57e-09

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

7 of 21

1.96

4.09

1.06e-10

SM00387

Histidine kinase-like ATPases

7 of 34

1.75

3.29

9.88e-10

SM00448

cheY-homologous receiver domain

5 of 42

1.51

1.82

1.30e-05

SM00073

Histidine Phosphotransfer domain

2 of 4

2.13

1.2

0.0054

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

2 of 10

1.73

0.87

0.0186

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About